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Synthetic applications of type II intramolecular cycloadditions
Long Min1; Ya-Jian Hu1,2; Jian-Hong Fan1,2; Wen Zhang1; Chuang-Chuang Li1
Source PublicationCHEMICAL SOCIETY REVIEWS
ISSN0306-0012
2020-09-01
Abstract

Type II intramolecular cycloadditions ([4+2], [4+3], [4+4] and [5+2]) have emerged recently as an efficient and powerful strategy for the construction of bridged ring systems. In general, type II cycloadditions provide access to a wide range of bridged bicyclo[m.n.1] ring systems with high regio- and diastereoselectivity in an easy and straightforward manner. In each section of this review, an overview of the corresponding type II cycloadditions is presented, which is followed by highlights of method development and synthetic applications in natural product synthesis. The goal of this review is to provide a survey of recent advances in the field covering literature up to 2020. The review will serve as a useful reference for organic chemists engaged in the total synthesis of natural products containing bridged bicyclo[m.n.1] ring systems and provide strong stimulus for invention and further advances in this exciting research field.

Language英語English
DOI10.1039/d0cs00365d
URLView the original
Volume49
Issue19
Pages7015-7043
WOS IDWOS:000575023000007
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
Indexed BySCIE
Scopus ID2-s2.0-85092682542
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Citation statistics
Document TypeReview article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChuang-Chuang Li
Affiliation1.henzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China
2.Institute of Chinese Medical Sciences, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Long Min,Ya-Jian Hu,Jian-Hong Fan,et al. Synthetic applications of type II intramolecular cycloadditions[J]. CHEMICAL SOCIETY REVIEWS, 2020, 49(19), 7015-7043.
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