Residential College | false |
Status | 已發表Published |
Analysis of Effect of Schisandra in the Treatment of Myocardial Infarction Based on Three-Mode Gene Ontology Network | |
Siyao Hu1; Huali Zuo2; Jin Qi1; Yuanjia Hu2; Boyang Yu1 | |
2019-03-20 | |
Source Publication | FRONTIERS IN PHARMACOLOGY |
ISSN | 1663-9812 |
Volume | 10 |
Other Abstract | Schisandra chinensis is a commonly used traditional Chinese medicine, which has been widely used in the treatment of acute myocardial infarction in China. However, it has been difficult to systematically clarify the major pharmacological effect of Schisandra, due to its multi-component complex mechanism. In order to solve this problem, a comprehensive network analysis method was established based-on “component– gene ontology–effect” interactions. Through the network analysis, reduction of cardiac preload and myocardial contractility was shown to be the major effect of Schisandra components, which was further experimentally validated. In addition, the expression of NCOR2 and NFAT in myocyte were experimentally confirmed to be associated with Schisandra in the treatment of AMI, which may be responsible for the preservation effect of myocardial contractility. In conclusion, the three-mode gene ontology network can be an effective network analysis workflow to evaluate the pharmacological effects of a multi-drug complex system. |
Keyword | Schisandra Myocardial Infarction Effect Three-mode Network Gene Ontology |
DOI | 10.3389/fphar.2019.00232 |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Pharmacology & Pharmacy |
WOS Subject | Pharmacology & Pharmacy |
WOS ID | WOS:000461811900001 |
Scopus ID | 2-s2.0-85075127752 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences |
Corresponding Author | Yuanjia Hu; Boyang Yu |
Affiliation | 1.Jiangsu Key Laboratory of Traditional Medicine and Translational Research, China Pharmaceutical University, Nanjing, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau |
Corresponding Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Siyao Hu,Huali Zuo,Jin Qi,et al. Analysis of Effect of Schisandra in the Treatment of Myocardial Infarction Based on Three-Mode Gene Ontology Network[J]. FRONTIERS IN PHARMACOLOGY, 2019, 10. |
APA | Siyao Hu., Huali Zuo., Jin Qi., Yuanjia Hu., & Boyang Yu (2019). Analysis of Effect of Schisandra in the Treatment of Myocardial Infarction Based on Three-Mode Gene Ontology Network. FRONTIERS IN PHARMACOLOGY, 10. |
MLA | Siyao Hu,et al."Analysis of Effect of Schisandra in the Treatment of Myocardial Infarction Based on Three-Mode Gene Ontology Network".FRONTIERS IN PHARMACOLOGY 10(2019). |
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