Residential College | false |
Status | 已發表Published |
n-3 Polyunsaturated fatty acids for the management of alcoholic liverdisease: A critical review | |
Meng Wang1,2; Li-Juan Ma1; Yan Yang3; Zeyu Xia4; jian-Bo Wan1 | |
2019-07 | |
Conference Name | 3rd International Symposium on Phytochemicals in Medicine and Food (ISPMF) |
Source Publication | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION |
Conference Date | 2018-8 |
Conference Place | Kunming, PEOPLES R CHINA |
Abstract | Excess alcohol exposure leads to alcoholic liver disease (ALD), a predominant cause of liver-related morbidity and mortality worldwide. In the past decade, increasing attention has been paid to understand the association between n-3 polyunsaturated fatty acids (n-3 PUFAs) and ALD. In this review, we summarize the metabolism of n-3 PUFAs, animal model of ALD, and the findings from recent studies determining the role of n-3 PUFAs in ALD as a possible treatment. The animal models of acute ethanol exposure, chronic ethanol exposure and chronic-plus-single binge ethanol feeding have been widely used to explore the impact of n-3 PUFAs. Although the results of studies regarding the role of n-3 PUFAs in ALD have been inconsistent or controversial, increasing evidence has demonstrated that n-3 PUFAs may be useful in alleviating alcoholic steatosis and alcohol-induced liver injury through multiple mechanisms, including decreased de novo lipogenesis and lipid mobilization from adipose tissue, enhanced mitochondrial fatty acid β-oxidation, reduced hepatic inflammation and oxidative stress, and promoted intestinal homeostasis, positively suggesting that n-3 PUFAs might be promising for the management of ALD. The oxidation of n-3 PUFAs ex vivo in an experimental diet was rarely considered in most n-3 PUFA-related studies, likely contributing to the inconsistent results. Thus, the role of n-3 PUFAs in ALD deserves greater research efforts and remains to be evaluated in randomized, placebo-controlled clinic trial. |
Keyword | Alcoholic Liver Disease Alcoholic Steatosis Intestinal Homeostasis Inflammation N-3 Polyunsaturated Fatty Acids Oxidative Stress |
DOI | 10.1080/10408398.2018.1544542 |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Food Science & Technology ; Nutrition & Dietetics |
WOS Subject | Food Science & Technology ; Nutrition & Dietetics |
WOS ID | WOS:000470673800009 |
Scopus ID | 2-s2.0-85067197044 |
Fulltext Access | |
Citation statistics | |
Document Type | Conference paper |
Collection | Institute of Chinese Medical Sciences |
Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao,China 2.Collaborative Translational Medicine CollaborativeInnovation Center, Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University Schoolof Medicine, Shanghai, China 3.Center for Drug Innovation and Discovery, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, China 4.Departmentof Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China |
First Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Meng Wang,Li-Juan Ma,Yan Yang,et al. n-3 Polyunsaturated fatty acids for the management of alcoholic liverdisease: A critical review[C], 2019. |
APA | Meng Wang., Li-Juan Ma., Yan Yang., Zeyu Xia., & jian-Bo Wan (2019). n-3 Polyunsaturated fatty acids for the management of alcoholic liverdisease: A critical review. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION. |
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