Iridium(III) complexes with 1,10-phenanthrolinebased N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection

doi:10.1039/c6tb02316a

UM > Faculty of Science and Technology > DEPARTMENT OF MATHEMATICS

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	Iridium(III) complexes with 1,10-phenanthrolinebased N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection
	Lu, LH 1,2; Wang, WH 2; Yang, C3 ; Kang, TS 3; Leung, CH3 ; Ma, DL 2
	2016
Source Publication	JOURNAL OF MATERIALS CHEMISTRY B
ISSN	2050-750X
Volume	4 Issue:42 Pages:6791-6796
Abstract	A systematic study was performed to investigate the relationship between molecular structure and G-quadruplex sensing ability for a series of structurally related cyclometallated iridium(III) complexes. The novel complex 7 was used to construct a label-free luminescent switch-on G-quadruplex-based assay for RNase H activity in buffered solution. The constructed detection platform was simple, low-cost and highly sensitive for RNase H, and functioned effectively in the presence of cellular debris.
DOI	10.1039/c6tb02316a
Indexed By	SCIE
Language	英語English
WOS Research Area	Materials Science
WOS Subject	Materials Science, bioMaterials
WOS ID	WOS:000387225800004
Scopus ID	2-s2.0-84993940466
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science
Citation statistics
Document Type	Journal article
Collection	DEPARTMENT OF MATHEMATICS Institute of Chinese Medical Sciences
Corresponding Author	Lu, LH; Leung, CH; Ma, DL
Affiliation	1.Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China 2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China 3.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
Corresponding Author Affilication	University of Macau
Recommended Citation GB/T 7714	Lu, LH,Wang, WH,Yang, C,et al. Iridium(III) complexes with 1,10-phenanthrolinebased N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection[J]. JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4(42), 6791-6796.
APA	Lu, LH., Wang, WH., Yang, C., Kang, TS., Leung, CH., & Ma, DL (2016). Iridium(III) complexes with 1,10-phenanthrolinebased N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection. JOURNAL OF MATERIALS CHEMISTRY B, 4(42), 6791-6796.
MLA	Lu, LH,et al."Iridium(III) complexes with 1,10-phenanthrolinebased N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection".JOURNAL OF MATERIALS CHEMISTRY B 4.42(2016):6791-6796.

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