Graphic Processing Units (GPU) and kinetic sensors are promising devices of Internet of Things (IoT) computing environments in various application domains, including mobile healthcare. In this chapter a novel training/testing process for building/testing a classification model for unusual human activities (UHA) using ensembles of Neural Networks running on NVIDIA GPUs is proposed. Traditionally, UHA is done by a classifier that learns what activities a person is doing by training with skeletal data obtained from a motion sensor such as Microsoft Kinect [1]. These skeletal data are the spatial coordinates (x, y, z) of different parts of the human body. The numeric information forms time series, temporal records of movement sequences that can be used for training an ensemble of Neural Networks. In addition to the spatial features that describe current positions in the skeletal data, new features called shadow features are used to improve the supervised learning efficiency of the ensemble of Neural Networks running on an NVIDIA GPU card. Shadow features are inferred from the dynamics of body movements, thereby modelling the underlying momentum of the performed activities. They provide extra dimensions of information for characterizing activities in the classification process and thus significantly improving the accuracy. We show that the accuracy of using a Neural Network as a classifier on a data set with shadow features can still be further increased when more than one Neural Network is used, forming an ensemble of networks. In order to accelerate the processing speed of an ensemble of Neural Networks, the model proposed is designed and optimized to run on NIVDIA GPUs with CUDA.