| Residential College | false |
| Status | 已發表Published |
| Transplantation of multipotent IsI1+cardiac progenitor cells preserves infarcted heart function in mice | |
| Li, Yunpeng; Tian, Shuo; Lei, Ienglam; Liu, Liu; Ma, Peter; Wang, Zhong | |
| 2017 | |
| Source Publication | AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
 |
| ISSN | 1943-8141 |
| Volume | 9Issue:3Pages:1530-+ |
| Abstract | Cell-based cardiac therapy is a promising therapeutic strategy to restore heart function after myocardial infarction (MI). However, the cell type selection and ensuing effects remain controversial. Here, we intramyocardially injected IsI1+ cardiac progenitor cells (CPCs) derived from EGFP/luciferase double-tagged mouse embryonic stem (dt-mES) cells with vehicle (fibrin gel) or phosphate-buffered saline (PBS) into the infarcted area in nude mice to assess the contribution of CPCs to the recovery of cardiac function post-MI. Our results showed that IsI1+ CPCs differentiated normally into three cardiac lineages (cardiomyocytes (CMs), endothelial cells and smooth muscle cells) both on cell culture plates and in fibrin gel. Cell retention was significantly increased when the transplanted cells were injected with vehicle. Importantly, 28 days after injection, CPCs were observed to differentiate into CMs within the infarcted area. Moreover, numerous CD31+ endothelial cells derived from endogenous revascularization and differentiation of the injected CPCs were detected. SMMHC-, Ki67-and CX-43-positive cells were identified in the injected CPC population, further demonstrating the proliferation, differentiation and integration of the transplanted CPCs in host cells. Furthermore, animal hearts injected with CPCs showed increased angiogenesis, decreased infarct size, and improved heart function. In conclusion, our studies showed that IsI1+ CPCs, when combined with a suitable vehicle, can produce notable therapeutic effects in the infarcted heart, suggesting that CPCs might be an ideal cell source for cardiac therapy. |
| Keyword | Heart regeneration myocardial infarction cardiac progenitor cell cardiac function |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Oncology ; Research & Experimental Medicine |
| WOS Subject | Oncology ; Medicine, Research & Experimental |
| WOS ID | WOS:000399028800064 |
| Publisher | E-CENTURY PUBLISHING CORP |
| The Source to Article | WOS |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Recommended Citation GB/T 7714 | Li, Yunpeng,Tian, Shuo,Lei, Ienglam,et al. Transplantation of multipotent IsI1+cardiac progenitor cells preserves infarcted heart function in mice[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2017, 9(3), 1530-+. |
| APA | Li, Yunpeng., Tian, Shuo., Lei, Ienglam., Liu, Liu., Ma, Peter., & Wang, Zhong (2017). Transplantation of multipotent IsI1+cardiac progenitor cells preserves infarcted heart function in mice. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 9(3), 1530-+. |
| MLA | Li, Yunpeng,et al."Transplantation of multipotent IsI1+cardiac progenitor cells preserves infarcted heart function in mice".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 9.3(2017):1530-+. |
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