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Status | 已發表Published |
A Handheld High-Sensitivity Micro-NMR CMOS Platform With B-Field Stabilization for Multi-Type Biological/Chemical Assays | |
Lei, Ka-Meng1; Heidari, Hadi2; Mak, Pui-In1; Law, Man-Kay1; Maloberti, Franco2; Martins, Rui P.1 | |
2017-01 | |
Source Publication | IEEE JOURNAL OF SOLID-STATE CIRCUITS |
ISSN | 0018-9200 |
Volume | 52Issue:1Pages:284-297 |
Abstract | We report a micro-nuclear magnetic resonance (NMR) system compatible with multi-type biological/chemical lab-on-a- chip assays. Unified in a handheld scale (dimension: 14 x 6 x 11 cm(3), weight: 1.4 kg), the system is capable to detect < 100 pM of Enterococcus faecalis derived DNA from a 2.5 mu L sample. The key components are a portable magnet (0.46 T, 1.25 kg) for nucleus magnetization, a system PCB for I/O interface, an FPGA for system control, a current driver for trimming the magnetic (B) field, and a silicon chip fabricated in 0.18 mu m CMOS. The latter, integrated with a current-mode vertical Hall sensor and a low-noise readout circuit, facilitates closed-loop B-field stabilization (2 mT -> 0.15 mT), which otherwise fluctuates with temperature or sample displacement. Together with a dynamic-B-field transceiver with a planar coil for micro-NMR assay and thermal control, the system demonstrates: 1) selective biological target pinpointing; 2) protein state analysis; and 3) solvent-polymer dynamics, suitable for healthcare, food and colloidal applications, respectively. Compared to a commercial NMR-assay product (Bruker mq-20), this platform greatly reduces the sample consumption (120x), hardware volume (175x), and weight (96x). |
Keyword | Baseband Biological Biosensor Chemicalcmos Deoxyribonucleic Acid (Dna) Filter Hall Sensor Immunoglobulin Lab-on-a-chip Low-noise Amplifier (Lna) Magnetic Sensing Nuclear Magnetic Resonance (Nmr) Pointof-care Polymer Power Amplifier (Pa) Protein Radio Frequency (Rf) Receiver (Rx) Transceiver (Trx) Transimpedance Amplifier (Tia) Transmitter (Tx) |
DOI | 10.1109/JSSC.2016.2591551 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Engineering |
WOS Subject | Engineering, Electrical & Electronic |
WOS ID | WOS:000395641800025 |
Publisher | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC |
The Source to Article | WOS |
Scopus ID | 2-s2.0-84981724962 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | THE STATE KEY LABORATORY OF ANALOG AND MIXED-SIGNAL VLSI (UNIVERSITY OF MACAU) Faculty of Science and Technology INSTITUTE OF MICROELECTRONICS DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING |
Corresponding Author | Mak, Pui-In |
Affiliation | 1.State-Key Laboratory of Analog and Mixed-Signal VLSI and FST-ECE, University of Macau, Macao, China 2.University of Pavia, Pavia, Italy |
First Author Affilication | Faculty of Science and Technology |
Corresponding Author Affilication | Faculty of Science and Technology |
Recommended Citation GB/T 7714 | Lei, Ka-Meng,Heidari, Hadi,Mak, Pui-In,et al. A Handheld High-Sensitivity Micro-NMR CMOS Platform With B-Field Stabilization for Multi-Type Biological/Chemical Assays[J]. IEEE JOURNAL OF SOLID-STATE CIRCUITS, 2017, 52(1), 284-297. |
APA | Lei, Ka-Meng., Heidari, Hadi., Mak, Pui-In., Law, Man-Kay., Maloberti, Franco., & Martins, Rui P. (2017). A Handheld High-Sensitivity Micro-NMR CMOS Platform With B-Field Stabilization for Multi-Type Biological/Chemical Assays. IEEE JOURNAL OF SOLID-STATE CIRCUITS, 52(1), 284-297. |
MLA | Lei, Ka-Meng,et al."A Handheld High-Sensitivity Micro-NMR CMOS Platform With B-Field Stabilization for Multi-Type Biological/Chemical Assays".IEEE JOURNAL OF SOLID-STATE CIRCUITS 52.1(2017):284-297. |
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