| Residential College | false |
| Status | 已發表Published |
| Inhibition of TLR1/2 dimerization by enantiomers of metal complexes (vol 52, pg 12278, 2016) | |
Liu, Li-Juan1 ; Wang, Wanhe2; Zhong, Zhangfeng1 ; Lin, Sheng2; Lu, Lihua1; Wang, Yi-Tao1; Ma, Dik-Lung2 ; Leung, Chung-Hang1
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| 2016 | |
| Source Publication | CHEMICAL COMMUNICATIONS
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| ISSN | 1359-7345 |
| Volume | 53Issue:7Pages:1325-1325 |
| Abstract | We report herein the identification of an immunomodulatory metal-based complex 1 as a direct inhibitor of TLR1/2 heterodimerization. Both enantiomers of complex 1 selectively suppressed TNF-α and TLR1/2 heterodimerization in Pam3CSK4-induced macrophages, with Λ-1 being more potent than Δ-1. Moreover, the complexes inhibited NF-κB transduction via the modulation of TLR1/2 signaling. To our knowledge, complex 1 is the first metal-based inhibitor of TLR1/2 heterodimerization reported to date. |
| DOI | 10.1039/c7cc90024d |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000394244000027 |
| Publisher | ROYAL SOC CHEMISTRY |
| The Source to Article | WOS |
| Scopus ID | 2-s2.0-85010635905 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Ma, Dik-Lung; Leung, Chung-Hang |
| Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China 2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, China |
| First Author Affilication | Institute of Chinese Medical Sciences |
| Corresponding Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Liu, Li-Juan,Wang, Wanhe,Zhong, Zhangfeng,et al. Inhibition of TLR1/2 dimerization by enantiomers of metal complexes (vol 52, pg 12278, 2016)[J]. CHEMICAL COMMUNICATIONS, 2016, 53(7), 1325-1325. |
| APA | Liu, Li-Juan., Wang, Wanhe., Zhong, Zhangfeng., Lin, Sheng., Lu, Lihua., Wang, Yi-Tao., Ma, Dik-Lung., & Leung, Chung-Hang (2016). Inhibition of TLR1/2 dimerization by enantiomers of metal complexes (vol 52, pg 12278, 2016). CHEMICAL COMMUNICATIONS, 53(7), 1325-1325. |
| MLA | Liu, Li-Juan,et al."Inhibition of TLR1/2 dimerization by enantiomers of metal complexes (vol 52, pg 12278, 2016)".CHEMICAL COMMUNICATIONS 53.7(2016):1325-1325. |
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