China's Pearl River Delta has become the largest urban area in the world in both size and population according to the World Bank Group Rice (Oryza sativa) serves as the major staple food for people in Pearl River Delta Unfortunately, rice is particularly vulnerable to the arsenic (As) uptake and accumulation compared to other cereal crops, thus posing a potential health threat to populations with high rice consumption. The development of potential strategies to reduce As accumulation in rice grains great importance. Two soil pot experiments conducted by using joint phosphorus (P) and silicon (Si) fertilization with soil and foliar applications to alleviate As accumulation in rice grown in As-spiked soil. The results indicated that soil fertilization generally increased rice biomass whereas foliar fertilization generally decreased rice biomass. Regardless of soil and foliar applications, Si and/or P fertilizers reduced As accumulation in rice grain by an average of 22% and 22%, respectively, compared to no fertilizer treatment. This study demonstrated that joint application of Si and P fertilizers, regardless of soil and foliar application, is appropriate option to minimize As accumulation in rice grain although foliar application may result in loss of rice yield.