Residential College | false |
Status | 已發表Published |
Characterization of potential driver mutations involved in human breast cancer by computational approaches | |
Rajendran, Barani Kumar; Deng, Chu-Xia | |
2017-07-25 | |
Source Publication | ONCOTARGET |
ISSN | 1949-2553 |
Volume | 8Issue:30Pages:50252-50272 |
Abstract | Breast cancer is the second most frequently occurring form of cancer and is also the second most lethal cancer in women worldwide. A genetic mutation is one of the key factors that alter multiple cellular regulatory pathways and drive breast cancer initiation and progression yet nature of these cancer drivers remains elusive. In this article, we have reviewed various computational perspectives and algorithms for exploring breast cancer driver mutation genes. Using both frequency based and mutational exclusivity based approaches, we identified 195 driver genes and shortlisted 63 of them as candidate drivers for breast cancer using various computational approaches. Finally, we conducted network and pathway analysis to explore their functions in breast tumorigenesis including tumor initiation, progression, and metastasis. |
Keyword | Driver Mutations Breast Cancer Cancer Drivers Breast Cancer Driver Genes Genetic Mutations |
DOI | 10.18632/oncotarget.17225 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Oncology ; Cell Biology |
WOS Subject | Oncology ; Cell Biology |
WOS ID | WOS:000406232400146 |
Publisher | IMPACT JOURNALS LLC |
The Source to Article | WOS |
Scopus ID | 2-s2.0-85025810782 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Faculty of Health Sciences |
Corresponding Author | Deng, Chu-Xia |
Affiliation | Cancer Research Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China |
First Author Affilication | Faculty of Health Sciences |
Corresponding Author Affilication | Faculty of Health Sciences |
Recommended Citation GB/T 7714 | Rajendran, Barani Kumar,Deng, Chu-Xia. Characterization of potential driver mutations involved in human breast cancer by computational approaches[J]. ONCOTARGET, 2017, 8(30), 50252-50272. |
APA | Rajendran, Barani Kumar., & Deng, Chu-Xia (2017). Characterization of potential driver mutations involved in human breast cancer by computational approaches. ONCOTARGET, 8(30), 50252-50272. |
MLA | Rajendran, Barani Kumar,et al."Characterization of potential driver mutations involved in human breast cancer by computational approaches".ONCOTARGET 8.30(2017):50252-50272. |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment