| Residential College | false |
| Status | 即將出版Forthcoming |
| Role of autophagy in myocardial remodeling after myocardial infarction | |
| Tian, Run Ze1,2; Zhuang, Dong Lin6; Vong, Chi Teng3,4; He, Xuyu2,8; Ouyang, Qing1,2; Liang, Jing Hua1; Guo, Yan Ping1,2; Wang, Yu Hong1; Zhao, Shuang7; Yuan, Haiyun1,5; Nasser, Moussa Ide1; Li, Ge1,2,5; Zhu, Ping1,2,5 | |
| 2024 | |
| Source Publication | Journal of Cardiovascular Pharmacology
 |
| ISSN | 0160-2446 |
| Abstract | Autophagy is the process of reusing the body's senescent and damaged cell components, which can be regarded as the cellular circulatory system. There are three distinct forms of autophagy: macro-Autophagy, micro-Autophagy, and chaperone-mediated autophagy. In the heart, autophagy is regulated mainly through mitophagy due to the metabolic changes of cardiomyocytes caused by ischemia and hypoxia. Myocardial remodeling is characterized by gradual heart enlargement, cardiac dysfunction, and extraordinary molecular changes. Cardiac remodeling after myocardial infarction is almost inevitable, which is the leading cause of heart failure. Autophagy has a protective effect on myocardial remodeling improvement. Autophagy can minimize cardiac remodeling by preventing misfolded protein accumulation and oxidative stress. This review summarizes the nestest molecular mechanisms of autophagy and myocardial remodeling, the protective effects, and the new target of autophagy medicine in cardiac remodeling. The future development and challenges of autophagy in heart disease are also summarized. |
| Keyword | Autophagy Cellular circulatory system Myocardial infarction Myocardial remodeling Oxidative stress |
| DOI | 10.1097/FJC.0000000000001646 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85208654965 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 519041, China 2.School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510641, China 3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao 4.Macau Centre for Research and Development in Chinese Medicine, University of Macau, 999078, Macao 5.Guangzhou Key Laboratory of Cardiac Pathogenesis and Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 519041, China 6.Department of Structural Heart Disease, National Center for Cardiovascular Disease, China and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China 7.Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510080, China 8.Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China |
| Recommended Citation GB/T 7714 | Tian, Run Ze,Zhuang, Dong Lin,Vong, Chi Teng,et al. Role of autophagy in myocardial remodeling after myocardial infarction[J]. Journal of Cardiovascular Pharmacology, 2024. |
| APA | Tian, Run Ze., Zhuang, Dong Lin., Vong, Chi Teng., He, Xuyu., Ouyang, Qing., Liang, Jing Hua., Guo, Yan Ping., Wang, Yu Hong., Zhao, Shuang., Yuan, Haiyun., Nasser, Moussa Ide., Li, Ge., & Zhu, Ping (2024). Role of autophagy in myocardial remodeling after myocardial infarction. Journal of Cardiovascular Pharmacology. |
| MLA | Tian, Run Ze,et al."Role of autophagy in myocardial remodeling after myocardial infarction".Journal of Cardiovascular Pharmacology (2024). |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment