| Residential College | false |
| Status | 已發表Published |
| Ferroptosis-Modulating Natural Products for Targeting Inflammation-Related Diseases: Challenges and Opportunities in Manipulating Redox Signaling | |
Liang, Yongyi1; Qiu, Shaojun1; Zou, Youwen1 ; Leung, Elaine Lai Han2,3,4; Luo, Lianxiang1
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| 2024-11-01 | |
| Source Publication | Antioxidants and Redox Signaling
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| ISSN | 1523-0864 |
| Volume | 41Issue:13-15Pages:976-991 |
| Abstract | Significance: Numerous disorders are linked to ferroptosis, a form of programmed cell death triggered by lipid peroxidation accumulation rather than apoptosis. Inflammation is the body’s defensive response to stimuli and is also caused by inflammatory chemicals that can harm the body. The treatment of inflammatory diseases by focusing on the signaling pathways and mechanisms of ferroptosis has emerged as a new area worthy of extensive research. Recent Advances: Studies in cellular and animal models of inflammatory diseases have shown that ferroptosis markers are activated and lipid peroxidation levels are increased. Natural products (NPs) are gaining importance due to their ability to target ferroptosis pathways, particularly the Nuclear factor E2-related factor 2 signaling pathway, thereby suppressing inflammation and the release of pro-inflammatory cytokines. Critical Issues: This article provides an overview of ferroptosis, focusing on the signaling pathways and mechanisms connecting it to inflammation. It also explores the potential use of NPs as a treatment for inflammatory diseases and ferroptosis. Future Directions: NPs offer unique advantages, including multicomponent properties, multi-bio-targeting capabilities, and minimal side effects. Further research may facilitate the early clinical application of NPs to develop innovative treatment strategies. Antioxid. Redox Signal. 41, 976–991. |
| Keyword | ferroptosis inflammation iron metabolism lipid peroxidation NPs |
| DOI | 10.1089/ars.2024.0556 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85200887632 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Affiliation | 1.School of Ocean and Tropical Medicine, The Marine Biomedical Research Institute of Guangdong Zhanjiang, Guangdong Medical University, Zhanjiang, China 2.Faculty of Health Sciences, Cancer Centre, University of Macau, Macao 3.MOE Frontiers Science Centre for Precision Oncology, University of Macau, Macao 4.State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao |
| Recommended Citation GB/T 7714 | Liang, Yongyi,Qiu, Shaojun,Zou, Youwen,et al. Ferroptosis-Modulating Natural Products for Targeting Inflammation-Related Diseases: Challenges and Opportunities in Manipulating Redox Signaling[J]. Antioxidants and Redox Signaling, 2024, 41(13-15), 976-991. |
| APA | Liang, Yongyi., Qiu, Shaojun., Zou, Youwen., Leung, Elaine Lai Han., & Luo, Lianxiang (2024). Ferroptosis-Modulating Natural Products for Targeting Inflammation-Related Diseases: Challenges and Opportunities in Manipulating Redox Signaling. Antioxidants and Redox Signaling, 41(13-15), 976-991. |
| MLA | Liang, Yongyi,et al."Ferroptosis-Modulating Natural Products for Targeting Inflammation-Related Diseases: Challenges and Opportunities in Manipulating Redox Signaling".Antioxidants and Redox Signaling 41.13-15(2024):976-991. |
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