Myricanol modulates skeletal muscle-adipose crosstalk to alleviate high fat diet-induced obesity and insulin resistance

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	已發表Published
	Myricanol modulates skeletal muscle-adipose crosstalk to alleviate high fat diet-induced obesity and insulin resistance
	Shen Shengnan1 ; Liao Qiwen1 ; Pan Ruile 2; LIN LIGEN1
	2019-10-17
Size of Audience	100
Type of Speaker	invited talk
Abstract	Skeletal muscle is the predominant site for glucose disposal and fatty acid consumption. Emerging evidences have indicated the crosstalk between adipose and skeletal muscle is critical in maintaining insulin sensitivity and lipid homeostasis. The current study was designed to investigate whether myricanol (MY) improves insulin sensitivity and alleviates adiposity through modulating skeletal muscle-adipose crosstalk. MY was found to increase mitochondrial quantity and function through activating AMP-activated protein kinase, resulting in reduced lipid accumulation and enhanced insulin-stimulated glucose uptake, in PA-treated C2C12 myobutes. Furthermore, MY stimulated irisin production and secretion from myotubes to reduce lipid content in 3T3-L1 adipocytes. In high fat diet-fed mice, MY treatment alleviated adiposity and insulin resistance through enhancing lipid utilization and irisin production in skeletal muscle, and subsequently browning of inguinal fat. Taken together, our results implicated that MY modulates skeletal muscle-adipose crosstalk, to alleviate adiposity, improve insulin sensitivity, and stimulate browning of adipose tissue. MY might be a potential candidate for treating insulin resistance and obesity.
Source Publication	XIII International Symposium on the Chemistry of Natural Compounds
Conference Place	Shanghai, China
Document Type	Presentation
Collection	Institute of Chinese Medical Sciences
Corresponding Author	LIN LIGEN
Affiliation	1.University of Macau 2.Institute of Medicinal Plant Development
First Author Affilication	University of Macau
Recommended Citation GB/T 7714	Shen Shengnan,Liao Qiwen,Pan Ruile,et al. Myricanol modulates skeletal muscle-adipose crosstalk to alleviate high fat diet-induced obesity and insulin resistance[Z]. XIII International Symposium on the Chemistry of Natural Compounds

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh