In this paper, a hybrid mass sensing system including a 2-DOF coupled resonator (CR) and a clamped-clamped beam (CCB) is reported, in which the frequency difference between two coupled modes of CR is identical to the resonant frequency of CCB. Therefore, the modal coupling of CR can be dynamically controlled by the resonant frequency of CCB. When a mass perturbation is introduced to CCB, the modal coupling in CR is enhanced significantly and the coupling ratio between the anti-phase and in-phase modes is investigated. The coupling ratio normalized sensitivity can be increased by two orders of magnitude compared with other amplitude modulated based resonant mass sensors, up to 4704.