| Residential College | false |
| Status | 已發表Published |
| Recent design strategies for boosting chemodynamic therapy of bacterial infections | |
| Zhang, Junjie1; Guo, Haiyang1; Liu, Ming1; Tang, Kaiyuan1; Li, Shengke2; Fang, Qiang1; Du, Hengda1; Zhou, Xiaogang3; Lin, Xin4; Yang, Yanjun5; Huang, Bin6; Yang, Dongliang7 | |
| 2024-04-01 | |
| Source Publication | Exploration
 |
| ISSN | 2766-8509 |
| Volume | 4Issue:2 |
| Abstract | The emergence of drug-resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue to persist. Currently, antibiotic therapy remains the primary approach for tackling bacterial infections. However, the escalating rates of drug resistance coupled with the lag in the development of novel drugs have led to diminishing effectiveness of conventional treatments. Therefore, the development of nonantibiotic-dependent therapeutic strategies has become imperative to impede the rise of bacterial resistance. The emergence of chemodynamic therapy (CDT) has opened up a new possibility due to the CDT can convert HO into •OH via Fenton/Fenton-like reaction for drug-resistant bacterial treatment. However, the efficacy of CDT is limited by a variety of practical factors. To overcome this limitation, the sterilization efficiency of CDT can be enhanced by introducing the therapeutics with inherent antimicrobial capability. In addition, researchers have explored CDT-based combined therapies to augment its antimicrobial effects and mitigate its potential toxic side effects toward normal tissues. This review examines the research progress of CDT in the antimicrobial field, explores various strategies to enhance CDT efficacy and presents the synergistic effects of CDT in combination with other modalities. And last, the current challenges faced by CDT and the future research directions are discussed. |
| Keyword | antibacterial chemodynamic therapy combined therapy nanomaterials |
| DOI | 10.1002/EXP.20230087 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85183583903 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.School of Fundamental Sciences, Bengbu Medical College, Bengbu, China 2.Macao Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, SAR, Macao 3.Anhui Key Laboratory of Infection and Immunity, School of Basic Medicine, Bengbu Medical College, Bengbu, China 4.School of Optometry and Ophthalmology and Eye Hospital, State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou Medical University, Wenzhou, Zhejiang, China 5.School of Electrical and Computer Engineering, College of Engineering, The University of Georgia, Athens, United States 6.Academy of Integrative Medicine, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China 7.Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing, China |
| Recommended Citation GB/T 7714 | Zhang, Junjie,Guo, Haiyang,Liu, Ming,et al. Recent design strategies for boosting chemodynamic therapy of bacterial infections[J]. Exploration, 2024, 4(2). |
| APA | Zhang, Junjie., Guo, Haiyang., Liu, Ming., Tang, Kaiyuan., Li, Shengke., Fang, Qiang., Du, Hengda., Zhou, Xiaogang., Lin, Xin., Yang, Yanjun., Huang, Bin., & Yang, Dongliang (2024). Recent design strategies for boosting chemodynamic therapy of bacterial infections. Exploration, 4(2). |
| MLA | Zhang, Junjie,et al."Recent design strategies for boosting chemodynamic therapy of bacterial infections".Exploration 4.2(2024). |
| Files in This Item: | There are no files associated with this item. | |||||
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