| Residential College | false |
| Status | 已發表Published |
| Photocatalytic Carbon Dots-Triggered Pyroptosis for Whole Cancer Cell Vaccines | |
| Cheng, Quansheng1; Zhang, Tesen1; Wang, Qingcheng1; Wu, Xue1; Li, Lingyun1; Lin, Runxing1; Zhou, Yinning1,2,3; Qu, Songnan1,2,3,4 | |
| 2024-09-26 | |
| Source Publication | Advanced Materials
 |
| ISSN | 0935-9648 |
| Volume | 36Issue:39 |
| Abstract | Manufacturing whole cancer cell vaccines (WCCV) with both biosafety and efficacy is crucial for tumor immunotherapy. Pyroptotic cancer cells, due to their highly immunogenic properties, present a promising avenue for the development of WCCV. However, the successful development of WCCV based on pyroptotic cancer cells is yet to be accomplished. Here, a facile strategy that utilized photocatalytic carbon dots (CDs) to induce pyroptosis of cancer cells for fabricating WCCV is reported. Photocatalytic CDs are capable of generating substantial amounts of hydroxyl radicals and can effectively decrease cytoplasmic pH values under white light irradiation. This process efficiently triggers cancer cell pyroptosis through the reactive oxygen species (ROS)-mitochondria-caspase 3-gasdermin E pathway and the proton motive force-driven mitochondrial ATP synthesis pathway. Moreover, in vitro, these photocatalytic CDs-induced pyroptotic cancer cells (PCIP) can hyperactivate macrophage (M0–M1) with upregulation of major histocompatibility complex class II expression. In vivo, PCIP induced specific immune-preventive effects in melanoma and breast cancer mouse models through anticancer immune memory, demonstrating effective WCCV. This work provides novel insights for inducing cancer cell pyroptosis and bridges the gap in the fabrication of WCCV based on pyroptotic cancer cells. |
| Keyword | photocatalytic carbon dots pyroptosis pyroptotic cancer cells whole cancer cell vaccines |
| DOI | 10.1002/adma.202408685 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85200992170 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, SAR, 999078, Macao 2.Department of Physics and Chemistry, Faculty of Science and Technology, University of Macau, Taipa, SAR, 999078, Macao 3.MOE Frontier Science Centre for Precision Oncology, Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, SAR, 999078, Macao 4.Zhuhai UM Science and Technology Research Institute, Zhuhai, 519031, China |
| First Author Affilication | INSTITUTE OF APPLIED PHYSICS AND MATERIALS ENGINEERING |
| Recommended Citation GB/T 7714 | Cheng, Quansheng,Zhang, Tesen,Wang, Qingcheng,et al. Photocatalytic Carbon Dots-Triggered Pyroptosis for Whole Cancer Cell Vaccines[J]. Advanced Materials, 2024, 36(39). |
| APA | Cheng, Quansheng., Zhang, Tesen., Wang, Qingcheng., Wu, Xue., Li, Lingyun., Lin, Runxing., Zhou, Yinning., & Qu, Songnan (2024). Photocatalytic Carbon Dots-Triggered Pyroptosis for Whole Cancer Cell Vaccines. Advanced Materials, 36(39). |
| MLA | Cheng, Quansheng,et al."Photocatalytic Carbon Dots-Triggered Pyroptosis for Whole Cancer Cell Vaccines".Advanced Materials 36.39(2024). |
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