Platelets Are Versatile Cells: Implications in Drug Developments Against Immune-Mediated Thrombocytopenia and Ischemic Stroke

UM > Faculty of Health Sciences > DEPARTMENT OF PHARMACEUTICAL SCIENCES

Residential College	false
Status	即將出版Forthcoming
	Platelets Are Versatile Cells: Implications in Drug Developments Against Immune-Mediated Thrombocytopenia and Ischemic Stroke
	ZHENG WENHUA
	2024-09-19
Size of Audience	100
Type of Speaker	Session Chair
Abstract	Platelets are small anucleate cells in blood circulation. Platelet adhesion and aggregation at the site of vascular injury are essential events to stop bleeding (hemostasis). However, the similar biological process of hemostasis may lead to vessel occlusion and pathogenic consequences (thrombosis). Thrombotic disorders in coronary and cereberal arteries are the most common mechanisms of heart attack and stroke.Recent studies also established that platelets are versatile cells, which actively contribute to inflammation, immune response and thrombo-inflammatory diseases (e.g.reperfusion injury in ischemic stroke). It has been documented for more than half century that fibrinogen is required for platelet aggregation, but we found that platelet aggregation still occur in mice lacking fibrinogen in intravital microscopy thrombosis model and established“fibrinogen-independent”platelet aggregation, in which platelet receptor GPIba (albβ3 integrin) is essential. We also found platelet receptor GPIba - von Willebrand factor (VWF) interaction mediates platelet adhesion and vessel occlusion, particular at high shear. Interestingly, although several drugs have been developed against GPHbIHa, no drug for patients has been available against GPIba.This presentation will introduce platelet versatilities and discuss potential new drugs in controlling immune-mediated thrombocytopenia (ITP and fetal and neonatal alloimmune thrombocytopenia) and thrombosis (ischemic stroke /other cardiovascular diseases).
Conference Date	2024-09-19
Conference Place	澳门大学E12-G004
Language	英語English
Document Type	Presentation
Collection	DEPARTMENT OF PHARMACEUTICAL SCIENCES
Recommended Citation GB/T 7714	ZHENG WENHUA. Platelets Are Versatile Cells: Implications in Drug Developments Against Immune-Mediated Thrombocytopenia and Ischemic Stroke, 2024-09-19.

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