| Residential College | false |
| Status | 已發表Published |
| Luminescent iridium(iii)-peptide bioconjugates for bioanalytical and biomedical applications | |
| Jing, Shaozhen1,4,5; Wu, Xiaolei1,4,5; Chan, Daniel Shiu Hin3; Nao, Sang Cuo2; Du, Jianxiong1; Wong, Chun Yuen3; Wang, Jing1,4,5; Leung, Chung Hang2,6,7,8; Wang, Wanhe1,4,5 | |
| 2024-05-08 | |
| Source Publication | Inorganic Chemistry Frontiers
 |
| Volume | 11Issue:12Pages:3400-3417 |
| Abstract | Iridium(iii) complexes are alternative bioimaging probes due to their tunable photophysical properties, but are limited by poor cell penetrability and high cytotoxicity. Recently, iridium(iii)-peptide bioconjugates have received significant attention as bifunctional molecules in bioanalytical and biomedical fields. Conjugation to peptides endows iridium(iii) complexes with specificity, potentially overcoming the side effects and drug resistance of metallodrugs, whilst enhancing cellular uptake due to the improved cell penetrability, low cytotoxicity and targetability of peptides. In this review, we briefly introduce the interactions between iridium(iii) complexes and amino acids/peptides, including coordination to amino acids and detection and/or inhibition of peptides. We describe imaging applications of iridium(iii)-peptide bioconjugates, involving direct coordination of functional peptides or ligand modification, for targeted imaging. Next, we present therapeutic and theranostic applications of iridium(iii)-peptide bioconjugates through targeting of DNA and proteins. Finally, we outline the challenges and future opportunities in the development of iridium(iii)-peptide bioconjugates for precision medicine. |
| DOI | 10.1039/d4qi00625a |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85193749888 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Xi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 127 West Youyi Road, Shaanxi, 710072, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 3.Department of Chemistry, City University of Hong Kong, Hong Kong, Tat Chee Avenue, Kowloon SAR, Hong Kong 4.Northwestern Polytechnical University, Chongqing Technology Innovation Center, Chongqing, 400000, China 5.Research & Development Institute of Northwestern, Polytechnical University in Shenzhen, Shenzhen, 45 South Gaoxin Road, 518057, China 6.Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macao 7.Macao Centre for Research and Development in Chinese Medicine, University of Macau, Taipa, Macao 8.MoE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macao |
| Recommended Citation GB/T 7714 | Jing, Shaozhen,Wu, Xiaolei,Chan, Daniel Shiu Hin,et al. Luminescent iridium(iii)-peptide bioconjugates for bioanalytical and biomedical applications[J]. Inorganic Chemistry Frontiers, 2024, 11(12), 3400-3417. |
| APA | Jing, Shaozhen., Wu, Xiaolei., Chan, Daniel Shiu Hin., Nao, Sang Cuo., Du, Jianxiong., Wong, Chun Yuen., Wang, Jing., Leung, Chung Hang., & Wang, Wanhe (2024). Luminescent iridium(iii)-peptide bioconjugates for bioanalytical and biomedical applications. Inorganic Chemistry Frontiers, 11(12), 3400-3417. |
| MLA | Jing, Shaozhen,et al."Luminescent iridium(iii)-peptide bioconjugates for bioanalytical and biomedical applications".Inorganic Chemistry Frontiers 11.12(2024):3400-3417. |
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