Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction

doi:10.1002/smll.202310325

Residential College	false
Status	已發表Published
	Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction
	Chen, Yangmengfan 1,2; Luo, Zeyu 1,2; Meng, Weikun 1,2; Liu, Kai 3; Chen, Qiqing 4; Cai, Yongrui 1,2; Ding, Zichuan 1,2; Huang, Chao 1,2; Zhou, Zongke 1,2; Jiang, Meng 5; Zhou, Liqiang 6
	2024-06-05
Source Publication	Small
ISSN	1613-6810
Volume	20 Issue:23
Abstract	Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon, particularly within the field of biomedical implantation. The presence of FBR poses a heavy burden on both the medical and socioeconomic systems. This review seeks to elucidate the protein “fingerprint” of implant materials, which is generated by the physiochemical properties of the implant materials themselves. In this review, the activity of macrophages, the formation of foreign body giant cells (FBGCs), and the development of fibrosis capsules in the context of FBR are introduced. Additionally, the relationship between various implant materials and FBR is elucidated in detail, as is an overview of the existing approaches and technologies employed to alleviate FBR. Finally, the significance of implant components (metallic materials and non-metallic materials), surface CHEMISTRY (charge and wettability), and physical characteristics (topography, roughness, and stiffness) in establishing the protein “fingerprint” of implant materials is also well documented. In conclusion, this review aims to emphasize the importance of FBR on implant materials and provides the current perspectives and approaches in developing implant materials with anti-FBR properties.
Keyword	biomaterial surface characterization foreign body reaction implant macrophage
DOI	10.1002/smll.202310325
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85181697750
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Orthopedic Research Institution, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China 2.Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China 3.Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China 4.Department of Ultrasound, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China 5.Emergency and Trauma Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China 6.MOE Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, SAR, 999078, Macao
Recommended Citation GB/T 7714	Chen, Yangmengfan,Luo, Zeyu,Meng, Weikun,et al. Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction[J]. Small, 2024, 20(23).
APA	Chen, Yangmengfan., Luo, Zeyu., Meng, Weikun., Liu, Kai., Chen, Qiqing., Cai, Yongrui., Ding, Zichuan., Huang, Chao., Zhou, Zongke., Jiang, Meng., & Zhou, Liqiang (2024). Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction. Small, 20(23).
MLA	Chen, Yangmengfan,et al."Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction".Small 20.23(2024).

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh