| Residential College | true |
| Status | 即將出版Forthcoming |
| β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's diseas | |
Xia Zhao; ZHENG WENHUA 
| |
| 2024-08 | |
| Conference Name | The 12th Annual Meeting of The Good Practice in Traditional Chinese Medicine Research Association |
| Conference Date | 2024-08-24-26 |
| Conference Place | Regency Art Hotel, Macau SAR, China |
| Abstract | Microglia-mediated neuroinflammation is closely related to the development of Alzheimer's disease (AD). In the early stages of the inflammation response, pattern recognition receptors (PRRs) play a key role in clearing damaged cells and defending against infection by recognizing endogenous and exogenous ligands. However, the regulation of pathogenic microglial activation and its role in AD pathology remains poorly understood. Here we showed that a pattern recognition receptor called Dectin-1, expressed on microglia, mediates the pro-inflammatory responses of beta-amyloid (Aβ). Knockout of Dectin-1 reduced Aβ1-42 (Aβ42)-induced microglial activation, inflammatory responses, and synaptic and cognitive deficits in Aβ42-infused AD mice. Similar results were obtained in the BV2 cellmodel. Mechanistically, we showed that Aβ42 could directly bind to Dectin-1,causing Dectin-1 homodimerization and activating downstream Syk/NF-κB signaling pathway to induce the expression of inflammatory factors and, in turn, AD pathology. These results suggest the important role of microglia Dectin-1 as a new direct receptor for Aβ42 in microglial activation and AD pathology and provide a potential therapeutic strategy for neuroinflammation in ADThis is the first study to identify Dectin-1 as a new Aβ42 receptor in AD pathology. We demonstrated that microglia Dectin-1 mediates Aβ42-induced Syk/NF-κB signaling pathway activation and inflammatory response and subsequently contributes to AD pathology and cognitive dysfunction. We provide evidence for the direct binding of Aβ42 to Dectin-1 and a deep understanding of the proinflammatory mechanism of Aβ4 |
| Other Abstract | This study was supported by the National Natural Science Foundation of China (21961142009 to G.L.), Zhejiang Provincial Key Scientific Project (2021C03041 to G.L.), Natural Science Foundation of Zhejiang province(LQ23H090018 to X.Z.) and Hangzhou medical college (00004F1RCYJ2109 to X.Z. |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | ZHENG WENHUA |
| Recommended Citation GB/T 7714 | Xia Zhao,ZHENG WENHUA. β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's diseas[C], 2024. |
| APA | Xia Zhao., & ZHENG WENHUA (2024). β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's diseas. . |
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