The effects of phase separation on chromatin modifications, transcriptional regulation and virulence in the human fungal pathogen Candida albicans

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	The effects of phase separation on chromatin modifications, transcriptional regulation and virulence in the human fungal pathogen Candida albicans
	LAN QING; WONG KOON HO
	2024-03
Size of Audience	200
Type of Speaker	Selected from abstract
Abstract	Candida albicans is an opportunistic pathogen that can live in the human body as a commensal and cause deadly infection when the immune system is compromised. C. albicans can colonize different niches and survive the wide range of stresses elicited from the host during infection. These abilities are mediated by rapid and dynamic transcriptional responses, which are tightly controlled at transcription levels (e.g. transcriptional activation, elongation, and termination) and chromatin modification. The phenomenon of liquid-liquid phase separation can rapidly trigger the formation and dissociation of cellular compartments for biomacromolecules like proteins and nucleic acids without physical barriers. The process is reversible and tunable by factors relevant to the infection process, such as pH, temperature, and salinity. Phase separation has been shown to play crucial roles in controlling various biological processes and pathways in many organisms. We hypothesize that phase separation is important for the transcriptional responses of pathogens during adaption to diverse environmental conditions and infection. This study investigated the role of phase separation on the transcription and pathogenicity processes in C. albicans.
Document Type	Presentation
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	WONG KOON HO
Affiliation	Faculty of Health Sciences, University of Macau
Recommended Citation GB/T 7714	LAN QING,WONG KOON HO. The effects of phase separation on chromatin modifications, transcriptional regulation and virulence in the human fungal pathogen Candida albicans

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