Uncovering important transcriptional regulations during conidiation and spore germination

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

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	Uncovering important transcriptional regulations during conidiation and spore germination
	WU PIN; WANG FANG; CHONG WENG IN WINNIE; WONG KOON HO
	2024-03
Conference Name	32nd Fungal Genetics Conference
Conference Date	12/03/2024
Conference Place	Asilomar Conference Ground
Country	USA
Abstract	Filamentous fungi have the remarkable ability to undergo asexual reproduction, generating an enormous quantity of spores (a.k.a. conidia). These spores serve as the primary means of dissemination, acting as infectious propagules for human and plant pathogens, as well as significant contributors to food spoilage. The germination of spores and their subsequent growth as hyphae under favorable conditions are critical processes for infection and food spoilage. Therefore, understanding the mechanisms underlying conidiation and spore germination holds not only biological importance but also clinical and agricultural implications. To gain insight into the molecular mechanisms of conidiation and spore germination, we performed active transcription profiling by ChIP-seq and transcriptome profiling by RNA-seq on Aspergillus nidulans at distinct stages of conidiation and germination with a high temporal resolution. Our results unveiled dynamic transcriptional and post-transcriptional changes throughout different stages of germination and conidiation. Each stage exhibited enrichment of distinct gene sets with specialized functions. For some of these gene sets, we have identified potential candidate transcriptional regulators that could serve as valuable drug targets for impeding conidiation and spore germination. Further characterization of these regulators holds great promise for the development of novel antifungal drugs for preventing human and plant fungal infections.
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	WONG KOON HO
Affiliation	Faculty of Health Sciences, University of Macau
Recommended Citation GB/T 7714	WU PIN,WANG FANG,CHONG WENG IN WINNIE,et al. Uncovering important transcriptional regulations during conidiation and spore germination[C], 2024.
APA	WU PIN., WANG FANG., CHONG WENG IN WINNIE., & WONG KOON HO (2024). Uncovering important transcriptional regulations during conidiation and spore germination. .

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