Land subsidence occurs in river delta areas. A comprehensive understanding of the factors contributing to land subsidence is crucial for effective geohazard mitigation and land planning. This study investigates the distribution characteristics and spatiotemporal evolution pattern of the land subsidence in the Pearl River Delta based on the InSAR-derived ground deformation data spanning 2016 to 2021; and, the effects of the influencing factors, including the Quaternary sediment thickness, land use classification, land reclamation, and subway construction and operation, on the subsidence are analyzed. The results unveil the presence of four major subsidence zones and several minor coastal subsidence bowls in the research area, with a total area of about 1100 km, all of which exhibit prolonged and intense subsidence. In the remaining regions, land subsidence predominantly exhibits weak and short-term occurrences. The subsidence in the study area follows a distinct linear evolutionary pattern with a slight rebound, potentially linked to the rise of groundwater levels. Regions with Quaternary sediment thickness surpassing 20 m, engaging in aquaculture or agricultural activities, and featuring reclaimed land are predisposed to prolonged and intense ground subsidence. In addition, the construction and operation of subway lines may induce ground subsidence, especially in geologically vulnerable areas. This study provides valuable insights into land subsidence research in delta regions.