Alkaline anion-exchange-membrane water electrolyzers (AEMWEs) using earth-abundant catalysts is a promising approach for the generation of green H. However, the AEMWEs with alkaline electrolytes suffer from poor performance at high current density compared to proton exchange membrane electrolyzers. Here, atomically dispersed Pt-Ru dual sites co-embedded in nanoporous nickel selenides (np/PtRu-NiSe) are developed by a rapid melt-quenching approach to achieve highly-efficient alkaline hydrogen evolution reaction. The np/PtRu-NiSe catalyst shows ampere-level current density with a low overpotential (46 mV at 10 mA cm and 225 mV at 1000 mA cm), low Tafel slope (32.4 mV dec), and excellent long-term durability, significantly outperforming the benchmark Pt/C catalyst and other advanced large-current catalysts. The remarkable HER performance of nanoporous PtRu-NiSe is attributed to the strong intracrystal electronic metal-support interaction (IEMSI) between Pt-Se-Ru sites and NiSe support which can greatly enlarge the charge redistribution density, reduce the energy barrier of water dissociation, and optimize the potential determining step. Furthermore, the assembled alkaline AEMWE with an ultralow Pt and Ru loading realizes an industrial-level current density of 1 A cm at 1.84 volts with high durability.