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Cross-Tracer and Cross-Scanner Transfer Learning-Based Attenuation Correction for Brain SPECT
Sun, Hao1; Du, Yu1; Lin, Ching Ni2; Jiang, Han1; Huang, Wenbo1; Chiu, Pai Yi3; Hung, Guang Uei4; Lu, Lijun5,6; Mok, Greta S.P.1
2024-07
Source PublicationIEEE Transactions on Radiation and Plasma Medical Sciences
ISSN2469-7311
Volume8Issue:6Pages:664-676
Abstract

This study aims to investigate robust attenuation correction (AC) by generating attenuation maps (μ-maps) from non-attenuation-corrected (NAC) brain SPECT data using transfer learning (TL). Four sets of brain SPECT data (4×30) were retrospectively collected: S-TRODAT-1, S-ECD, G-TRODAT-1 and G-ECD. A 3D attention-based conditional generative adversarial network was pre-trained using 22 paired 3D NAC SPECT images and corresponding CT μ-maps for four patient groups. Various numbers (n=4-22) of paired NAC SPECT and corresponding μ-maps from S-TRODAT-1 were then used to fine-tune (FT) the other three pre-trained DL networks, i.e., S-ECD, G-TRODAT-1 and G-ECD. All patients in S-TRODAT-1 group were tested on their own network (DL-AC), and on the pre-trained models with FT (FT-AC) and without FT (NFT-AC). The FT-AC methods used 22 (FT22), 12 (FT12), 8 (FT8), and 4 (FT4) paired data for FT, respectively. Our results show that FT22 and FT12 could outperform DL-AC for cross-tracer S-ECD and cross-scanner G-TRODAT-1 using CT-based AC (CT-AC) as the reference. FT22 also outperforms DL-AC for cross-tracer+cross-scanner G-ECD. FT8 performs comparably to DL-AC, while FT4 is worse than DL-AC but still better than NAC and NFT-AC in each group. Attenuation map generation is feasible for brain SPECT based on cross-tracer and/or cross-scanner FT-AC using a smaller number of patient data. The FT-AC performance improves as the number of data used for FT increases.

KeywordAttenuation Correction (Ac) Brain Spect 99mtc-trodat-1 99mtc-ecd Transfer Learning (Tl)
DOI10.1109/TRPMS.2024.3374207
URLView the original
Indexed ByESCI
Language英語English
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:001263718700005
PublisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 445 HOES LANE, PISCATAWAY, NJ 08855-4141
Scopus ID2-s2.0-85187332107
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Citation statistics
Document TypeJournal article
CollectionFaculty of Science and Technology
DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Corresponding AuthorHung, Guang Uei; Lu, Lijun; Mok, Greta S.P.
Affiliation1.Department of Electrical and Computer Engineering, Faculty of Science and Technology, Biomedical Imaging Laboratory (BIG), University of Macau, Taipa, China
2.Department of Nuclear Medicine, Show Chwan Memorial Hospital, Changhua County, Taiwan
3.Department of Neurology, Show Chwan Memorial Hospital, Changhua County, Taiwan
4.Department of Nuclear Medicine, Chang Bing Show Chwan Memorial Hospital, Lukang, Taiwan
5.School of Biomedical Engineering, Southern Medical University, Guangzhou, China
6.Pazhou Lab, Guangzhou 510330, China
First Author AffilicationFaculty of Science and Technology
Corresponding Author AffilicationFaculty of Science and Technology
Recommended Citation
GB/T 7714
Sun, Hao,Du, Yu,Lin, Ching Ni,et al. Cross-Tracer and Cross-Scanner Transfer Learning-Based Attenuation Correction for Brain SPECT[J]. IEEE Transactions on Radiation and Plasma Medical Sciences, 2024, 8(6), 664-676.
APA Sun, Hao., Du, Yu., Lin, Ching Ni., Jiang, Han., Huang, Wenbo., Chiu, Pai Yi., Hung, Guang Uei., Lu, Lijun., & Mok, Greta S.P. (2024). Cross-Tracer and Cross-Scanner Transfer Learning-Based Attenuation Correction for Brain SPECT. IEEE Transactions on Radiation and Plasma Medical Sciences, 8(6), 664-676.
MLA Sun, Hao,et al."Cross-Tracer and Cross-Scanner Transfer Learning-Based Attenuation Correction for Brain SPECT".IEEE Transactions on Radiation and Plasma Medical Sciences 8.6(2024):664-676.
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