Magnetic resonance imaging (MRI), based on Nuclear Magnetic Resonance (NMR), is an indispensable tool for contemporary medicine. Moreover, the advent of multi-nuclei MRI imaging, such as ¹H/¹⁹F imaging using perfluorocarbon (PFC) nanoparticles, can detail anatomical and molecular information in a single session. It has revolutionized the field of molecular diagnostics and therapy monitoring by offering unprecedented insights into the physiological and pathological processes. While ¹H MRI can reveal the object's anatomy, the ubiquitous presence of ¹H in biological materials hinders effectiveness in tracking specific substances within the body (e.g., targeted drug delivery). Contrarily, as natural ¹⁹F is rare inside the body, it can serve as a marker for tracing substances with high specificity, thereby providing an accurate measure of the disease's extent or treatment efficacy.