Residential College | false |
Status | 已發表Published |
Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review | |
Li, Aiqin1,2; Ma, Bin3; Hua, Shiyao4; Ping, Rui5; Ding, Lu1; Tian, Bingren1; Zhang, Xu1 | |
Source Publication | Carbohydrate Polymers |
ISSN | 0144-8617 |
2024-06-01 | |
Abstract | Different types of clinical wounds are difficult to treat while infected by bacteria. Wound repair involves multiple cellular and molecular interactions, which is a complicated process. However, wound repair often suffers from abnormal cellular functions or pathways that result in unavoidable side effects, so there is an urgent need for a material that can heal wounds quickly and with few side effects. Based on these needs, hydrogels with injectable properties have been confirmed to be able to undergo self-healing, which provides favorable conditions for wound healing. Notably, as a biopolymer with excellent easy-to-modify properties from a wide range of natural sources, chitosan can be used to prepare injectable hydrogel with multifunction for wound healing because of its outstanding flowability and injectability. Especially, chitosan-based hydrogels with marked biocompatibility, non-toxicity, and bio-adhesion properties are ideal for facilitating wound healing. In this review, the characteristics and healing mechanisms of different wounds are briefly summarized. In addition, the preparation and characterization of injectable chitosan hydrogels in recent years are classified. Additionally, the bioactive properties of this type of hydrogel in vitro and in vivo are demonstrated, and future trend in wound healing is prospected. |
Keyword | Antibacteria Chitosan Hemostasis Injectable Hydrogel Self-healing Wound Healing |
Language | 英語English |
DOI | 10.1016/j.carbpol.2024.121952 |
URL | View the original |
Volume | 333 |
Pages | 121952 |
WOS ID | WOS:001199912800001 |
WOS Subject | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
WOS Research Area | Chemistry ; Polymer Science |
Indexed By | SCIE |
Scopus ID | 2-s2.0-85185395803 |
Fulltext Access | |
Citation statistics | |
Document Type | Review article |
Collection | Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) |
Corresponding Author | Hua, Shiyao; Tian, Bingren; Zhang, Xu |
Affiliation | 1.Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China 2.Department of Day Ward, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750001, China 3.Department of Spine Surgery, Yinchuan Guolong Orthopedic Hospital, Yinchuan, Ningxia, 750001, China 4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao 5.Department of Endocrinology, The First People's Hospital of Yinchuan, Yinchuan, Ningxia, 750001, China |
Corresponding Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Li, Aiqin,Ma, Bin,Hua, Shiyao,et al. Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review[J]. Carbohydrate Polymers, 2024, 333, 121952. |
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