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Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review
Li, Aiqin1,2; Ma, Bin3; Hua, Shiyao4; Ping, Rui5; Ding, Lu1; Tian, Bingren1; Zhang, Xu1
Source PublicationCarbohydrate Polymers
ISSN0144-8617
2024-06-01
Abstract

Different types of clinical wounds are difficult to treat while infected by bacteria. Wound repair involves multiple cellular and molecular interactions, which is a complicated process. However, wound repair often suffers from abnormal cellular functions or pathways that result in unavoidable side effects, so there is an urgent need for a material that can heal wounds quickly and with few side effects. Based on these needs, hydrogels with injectable properties have been confirmed to be able to undergo self-healing, which provides favorable conditions for wound healing. Notably, as a biopolymer with excellent easy-to-modify properties from a wide range of natural sources, chitosan can be used to prepare injectable hydrogel with multifunction for wound healing because of its outstanding flowability and injectability. Especially, chitosan-based hydrogels with marked biocompatibility, non-toxicity, and bio-adhesion properties are ideal for facilitating wound healing. In this review, the characteristics and healing mechanisms of different wounds are briefly summarized. In addition, the preparation and characterization of injectable chitosan hydrogels in recent years are classified. Additionally, the bioactive properties of this type of hydrogel in vitro and in vivo are demonstrated, and future trend in wound healing is prospected.

KeywordAntibacteria Chitosan Hemostasis Injectable Hydrogel Self-healing Wound Healing
Language英語English
DOI10.1016/j.carbpol.2024.121952
URLView the original
Volume333
Pages121952
WOS IDWOS:001199912800001
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS Research AreaChemistry ; Polymer Science
Indexed BySCIE
Scopus ID2-s2.0-85185395803
Fulltext Access
Citation statistics
Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeReview article
CollectionInstitute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorHua, Shiyao; Tian, Bingren; Zhang, Xu
Affiliation1.Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China
2.Department of Day Ward, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750001, China
3.Department of Spine Surgery, Yinchuan Guolong Orthopedic Hospital, Yinchuan, Ningxia, 750001, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao
5.Department of Endocrinology, The First People's Hospital of Yinchuan, Yinchuan, Ningxia, 750001, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li, Aiqin,Ma, Bin,Hua, Shiyao,et al. Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review[J]. Carbohydrate Polymers, 2024, 333, 121952.
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