In e-marketplace, semantic document exchange is a methodology of providing exchangeable semantic documents, which ensures document writer, writer's computer, reader's computer and document reader to share a same understanding in meaning on any exchanged document, that is, a semantic document is exchangeable across any heterogeneous contexts. Existing methodologies for semantic document exchange, in general, can be categorized in three tracks such as document standardization, ontology engineering, and collaborative document engineering. This paper explores challenging trends and issues for semantic document exchange in e-business.