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Analysis and numerical investigation of bile flow dynamics within the strictured biliary duct
Peng, Tao1; Zhong, Yunlong2; Lin, Xiaodong1; Jiang, Bingyan3; Wang, Ping2; Jia, Yanwei1,4,5,6
2023-11
Source PublicationInternational Journal for Numerical Methods in Biomedical Engineering
ISSN2040-7939
Volume40Issue:2Pages:e3790
Abstract

The mechanics of bile flow in the biliary system plays an important role in studying bile stasis and gallstone formation. Bile duct stricture is an abnormal phenomenon that refers to the bile duct getting smaller or narrower. The main objective of this study is to study the influence of stricture on bile flow dynamics using numerical methods. We employed a numerical Computational Fluid Dynamics model of the bile flow within a strictured hepatic duct. We studied and compared the influence of stricture severity, stricture length, eccentricity, and bile flow property on the bile flow dynamics. The bile flow velocity, pressure distribution, pressure drop, and wall shear stress are provided in detail. The stricture alters the normal bile flow pattern and increases flow resistance. At the location upstream and downstream of the stricture, bile flow slows down. In the area of the stricture throat, bile flow is accelerated, and recirculation forms behind the stricture. The maximum pressure drop of the biliary system increases with the stricture length. The eccentricity makes the flow deflect away from the duct's centerline. The behavior of the deflected flow is significantly altered downstream of the stricture. Such bile flow behavior as deceleration and recirculation may lead to cholestasis. Stricture alters bile flow in the biliary tract, causing changes in biliary hydrodynamic indexes, which could potentially serve as an omen for gallstone formation and other related diseases. The consideration of the bile duct stricture could lead to better patient stratification.

KeywordBile Flow Dynamics Biliary Stricture Computational Fluid Dynamics Non-newtonian Fluid Wall Shear Stress
DOI10.1002/cnm.3790
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaEngineering ; Mathematical & Computational Biology ; Mathematics
WOS SubjectEngineering, Biomedical ; Mathematical & Computational Biology ; Mathematics, Interdisciplinary Applications
WOS IDWOS:001109035200001
PublisherWILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ
Scopus ID2-s2.0-85177561037
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Citation statistics
Document TypeJournal article
CollectionFaculty of Science and Technology
Faculty of Health Sciences
THE STATE KEY LABORATORY OF ANALOG AND MIXED-SIGNAL VLSI (UNIVERSITY OF MACAU)
INSTITUTE OF MICROELECTRONICS
DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau
Corresponding AuthorJiang, Bingyan; Wang, Ping; Jia, Yanwei
Affiliation1.Zhuhai UM Science & Technology Research Institute, Zhuhai, China
2.Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
3.State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Hunan, China
4.State Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macao
5.Faculty of Science and Technology – Electrical and Computer Engineering, University of Macau, Macao
6.MoE Frontiers Science Center for Precision Oncology, University of Macau, Macao
Corresponding Author AffilicationUniversity of Macau;  Faculty of Science and Technology
Recommended Citation
GB/T 7714
Peng, Tao,Zhong, Yunlong,Lin, Xiaodong,et al. Analysis and numerical investigation of bile flow dynamics within the strictured biliary duct[J]. International Journal for Numerical Methods in Biomedical Engineering, 2023, 40(2), e3790.
APA Peng, Tao., Zhong, Yunlong., Lin, Xiaodong., Jiang, Bingyan., Wang, Ping., & Jia, Yanwei (2023). Analysis and numerical investigation of bile flow dynamics within the strictured biliary duct. International Journal for Numerical Methods in Biomedical Engineering, 40(2), e3790.
MLA Peng, Tao,et al."Analysis and numerical investigation of bile flow dynamics within the strictured biliary duct".International Journal for Numerical Methods in Biomedical Engineering 40.2(2023):e3790.
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