Excessive CO₂ and food shortage are two grand challenges of human society.Directly converting CO₂ into food materials can simultaneously alleviate both,like what green crops do in nature. Nevertheless, natural photosynthesis hasa limited energy efficiency due to low activity and specificity of key enzymeD-ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO). To enhancethe efficiency, many prior studies focused on engineering the enzymes, butthis study chooses to learn from the nature to design more efficient reactors.This work is original in mimicking the stacked structure of thylakoids inchloroplasts to immobilize RuBisCO in a microreactor using the layer-by-layerstrategy, obtaining the continuous conversion of CO₂ into glucose precursorat 1.9 nmol min⁻¹ with enhanced activity (1.5 times), stability (≈8 times), andreusability (96% after 10 reuses) relative to the free RuBisCO. Themicroreactors are further scaled out from one to six in parallel and achieve theproduction at 15.8 nmol min⁻¹ with an energy conversion efficiency of 3.3times of rice, showing better performance of this artificial synthesis than NPS in terms of energy conversion efficiency. The exploration of the potential ofmass production would benefit both food supply and carbon neutralization.