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Research progress in clinical trials of stem cell therapy for stroke and neurodegenerative diseases
Yan, Shan Shan1; Campos de Souza, Senio2; Xie, Zhen Dong3; Bao, Yong Xin4
2023-03
Source PublicationIbrain
ISSN2313-1934
Volume9Issue:2Pages:214-230
Abstract

The incidence of stroke and neurodegenerative diseases is gradually increasing in modern society, but there is still no treatment that is effective enough. Stem cells are cells that can reproduce (self-renew) and differentiate into the body, which have shown significance in basic research, while doctors have also taken them into clinical trials to determine their efficacy and safety. Existing clinical trials mainly include middle-aged and elderly patients with stroke or Parkinson's disease (mostly 40–80 years old), mainly involving injection of mesenchymal stem cells and bone marrow mesenchymal stem cells through the veins and the putamen, with a dosage of mostly 10–10 cells. The neural and motor functions of the patients were restored after stem cell therapy, and the safety was found to be good during the follow-up period of 3 months to 5 years. Here, we review all clinical trials and the latest advances in stroke, Alzheimer's disease, and Parkinson's disease, with the hope that stem cell therapy will be used in the clinic in the future to achieve effective treatment rates and benefit patients.

KeywordAlzheimer's Disease Cerebral Hemorrhage Cerebral Ischemia Parkinson's Disease Stem Cell Treatment
DOI10.1002/ibra.12095
URLView the original
Language英語English
Scopus ID2-s2.0-85172123881
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Document TypeJournal article
CollectionTHE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Co-First AuthorYan, Shan Shan
Corresponding AuthorBao, Yong Xin
Affiliation1.Department of Anesthesiology, Southwest Medical University, Luzhou, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, SAR, Macao
3.Institute for Bioengineering of Catalonia, University of Barcelona, Barcelona, Carrer de Baldiri Reixac, Spain
4.Qingdao Women and Children's Hospital, Qingdao University, Qingdao, China
Recommended Citation
GB/T 7714
Yan, Shan Shan,Campos de Souza, Senio,Xie, Zhen Dong,et al. Research progress in clinical trials of stem cell therapy for stroke and neurodegenerative diseases[J]. Ibrain, 2023, 9(2), 214-230.
APA Yan, Shan Shan., Campos de Souza, Senio., Xie, Zhen Dong., & Bao, Yong Xin (2023). Research progress in clinical trials of stem cell therapy for stroke and neurodegenerative diseases. Ibrain, 9(2), 214-230.
MLA Yan, Shan Shan,et al."Research progress in clinical trials of stem cell therapy for stroke and neurodegenerative diseases".Ibrain 9.2(2023):214-230.
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