Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy

doi:10.1016/j.addr.2023.115110

UM > Faculty of Health Sciences > DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION

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	Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy
	Li, Songhao 1,2; Mok, Greta S.P.3; Dai, Yunlu1,2
	2023-11-01
Source Publication	Advanced Drug Delivery Reviews
ISSN	0169-409X
Volume	202
Abstract	Sonodynamic therapy (SDT) has been developed as a promising alternative therapeutic modality for cancer treatment, involving the synergetic application of sonosensitizers and low-intensity ultrasound. However, the antitumor efficacy of SDT is significantly limited due to the poor performance of conventional sonosensitizers in vivo and the constrained tumor microenvironment (TME). Recent breakthroughs in lipid bilayer-based nanovesicles (LBBNs), including multifunctional liposomes, exosomes, and isolated cellular membranes, have brought new insights into the advancement of SDT. Despite their distinct sources and preparation methods, the lipid bilayer structure in common allows them to be functionalized in many comparable ways to serve as ideal nanocarriers against challenges arising from the tumor-specific sonosensitizer delivery and the complicated TME. In this review, we provide a comprehensive summary of the recent advances in LBBN-based SDT, with particular attention on how LBBNs can be engineered to improve the delivery efficiency of sonosensitizers and overcome physical, biological, and immune barriers within the TME for enhanced sonodynamic cancer therapy. We anticipate that this review will offer valuable guidance in the construction of LBBN-based nanosonosensitizers and contribute to the development of advanced strategies for next-generation sonodynamic cancer therapy.
Keyword	Cancer Immunotherapy Cell Membrane Coating Exosomes Functional Liposomes Sonodynamic Therapy Tumor Microenvironment
DOI	10.1016/j.addr.2023.115110
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85174818350
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Corresponding Author	Dai, Yunlu
Affiliation	1.Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China 2.MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, 999078, China 3.Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau SAR, 999078, China
First Author Affilication	Cancer Centre; University of Macau
Corresponding Author Affilication	Cancer Centre; University of Macau
Recommended Citation GB/T 7714	Li, Songhao,Mok, Greta S.P.,Dai, Yunlu. Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy[J]. Advanced Drug Delivery Reviews, 2023, 202.
APA	Li, Songhao., Mok, Greta S.P.., & Dai, Yunlu (2023). Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy. Advanced Drug Delivery Reviews, 202.
MLA	Li, Songhao,et al."Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy".Advanced Drug Delivery Reviews 202(2023).

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