| Residential College | false |
| Status | 已發表Published |
| Therapeutic potential of tumor treating fields for malignant brain tumors | |
| Zhou, Youyou1,2,3; Xing, Xiaoqing1,2,3; Zhou, Jinyun1,2,3; Jiang, Han4; Cen, Peili1,2,3; Jin, Chentao1,2,3; Zhong, Yan1,2,3; Zhou, Rui1,2,3; Wang, Jing1,2,3; Tian, Mei1,2,3,5; Zhang, Hong1,2,3,6,7 | |
| 2023-05-01 | |
| Source Publication | Cancer Reports
 |
| Volume | 6Issue:5 |
| Abstract | Background: Malignant brain tumors are among the most threatening diseases of the central nervous system, and despite increasingly updated treatments, the prognosis has not been improved. Tumor treating fields (TTFields) are an emerging approach in cancer treatment using intermediate-frequency and low-intensity electric field and can lead to the development of novel therapeutic options. Recent Findings: A series of biological processes induced by TTFields to exert anti-cancer effects have been identified. Recent studies have shown that TTFields can alter the bioelectrical state of macromolecules and organelles involved in cancer biology. Massive alterations in cancer cell proteomics and transcriptomics caused by TTFields were related to cell biological processes as well as multiple organelle structures and activities. This review addresses the mechanisms of TTFields and recent advances in the application of TTFields therapy in malignant brain tumors, especially in glioblastoma (GBM). Conclusions: As a novel therapeutic strategy, TTFields have shown promising results in many clinical trials, especially in GBM, and continue to evolve. A growing number of patients with malignant brain tumors are being enrolled in ongoing clinical studies demonstrating that TTFields-based combination therapies can improve treatment outcomes. |
| Keyword | alternating electric field cancer therapy glioblastoma malignant brain tumors tumor treating fields |
| DOI | 10.1002/cnr2.1813 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85152052103 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China 2.Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, Zhejiang, China 3.Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang, China 4.Faculty of Science and Technology, Department of Electrical and Computer Engineering, Biomedical Imaging Laboratory (BIG), University of Macau, Taipa, Macao 5.Human Phenome Institute, Fudan University, Shanghai, China 6.College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China 7.Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, China |
| Recommended Citation GB/T 7714 | Zhou, Youyou,Xing, Xiaoqing,Zhou, Jinyun,et al. Therapeutic potential of tumor treating fields for malignant brain tumors[J]. Cancer Reports, 2023, 6(5). |
| APA | Zhou, Youyou., Xing, Xiaoqing., Zhou, Jinyun., Jiang, Han., Cen, Peili., Jin, Chentao., Zhong, Yan., Zhou, Rui., Wang, Jing., Tian, Mei., & Zhang, Hong (2023). Therapeutic potential of tumor treating fields for malignant brain tumors. Cancer Reports, 6(5). |
| MLA | Zhou, Youyou,et al."Therapeutic potential of tumor treating fields for malignant brain tumors".Cancer Reports 6.5(2023). |
| Files in This Item: | There are no files associated with this item. | |||||
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