| Residential College | false |
| Status | 已發表Published |
| Chemical derivatization strategy for mass spectrometry-based lipidomics | |
| Xia, Fangbo; Wan, Jian Bo | |
| 2023 | |
| Source Publication | Mass Spectrometry Reviews
 |
| ISSN | 0277-7037 |
| Volume | 42Issue:1Pages:432-452 |
| Abstract | Lipids, serving as the structural components of cellular membranes, energy storage, and signaling molecules, play the essential and multiple roles in biological functions of mammals. Mass spectrometry (MS) is widely accepted as the first choice for lipid analysis, offering good performance in sensitivity, accuracy, and structural characterization. However, the untargeted qualitative profiling and absolute quantitation of lipids are still challenged by great structural diversity and high structural similarity. In recent decade, chemical derivatization mainly targeting carboxyl group and carbon-carbon double bond of lipids have been developed for lipidomic analysis with diverse advantages: (i) offering more characteristic structural information; (ii) improving the analytical performance, including chromatographic separation and MS sensitivity; (iii) providing one-to-one chemical isotope labeling internal standards based on the isotope derivatization regent in quantitative analysis. Moreover, the chemical derivatization strategy has shown great potential in combination with ion mobility mass spectrometry and ambient mass spectrometry. Herein, we summarized the current states and advances in chemical derivatization-assisted MS techniques for lipidomic analysis, and their strengths and challenges are also given. In summary, the chemical derivatization-based lipidomic approach has become a promising and reliable technique for the analysis of lipidome in complex biological samples. |
| Keyword | chemical derivatization chemical isotope labeling ion mobility mass spectrometry lipidomics mass spectrometry |
| DOI | 10.1002/mas.21729 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85114353931 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao |
| First Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Xia, Fangbo,Wan, Jian Bo. Chemical derivatization strategy for mass spectrometry-based lipidomics[J]. Mass Spectrometry Reviews, 2023, 42(1), 432-452. |
| APA | Xia, Fangbo., & Wan, Jian Bo (2023). Chemical derivatization strategy for mass spectrometry-based lipidomics. Mass Spectrometry Reviews, 42(1), 432-452. |
| MLA | Xia, Fangbo,et al."Chemical derivatization strategy for mass spectrometry-based lipidomics".Mass Spectrometry Reviews 42.1(2023):432-452. |
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