We are concerned with the monic orthogonal polynomials with respect to a singularly perturbed Laguerre-type weight. By using the ladder operator approach, we derive a complicated system of nonlinear second-order difference equations satisfied by the recurrence coefficients. This allows us to derive the large n asymptotic expansions of the recurrence coefficients. In addition, we also obtain a system of differential-difference equations for the recurrence coefficients.