| Residential College | false |
| Status | 已發表Published |
| Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work | |
| Yuan, Mingzhe2; Chen, Shan3; Zeng, Chu2; Fan, Yuqin1; Ge, Wei2; Chen, Weiting1 | |
| 2023-06-01 | |
| Source Publication | Environment International
 |
| ISSN | 0160-4120 |
| Volume | 176 |
| Abstract | Bisphenol A (BPA) is the most simple and predominant component of the Bisphenol family. BPA is widely present in the environment and the human body as a result of its extensive usage in the plastic and epoxy resins of consumer goods like water bottles, food containers, and tableware. Since the 1930s, when BPA's estrogenic activity was first observed, and it was labeled as a “mimic hormone of E2”, studies on the endocrine-disrupting effects of BPA then have been widely conducted. As a top vertebrate model for genetic and developmental studies, the zebrafish has caught tremendous attention in the past two decades. By using the zebrafish, the negative effects of BPA either through estrogenic signaling pathways or non-estrogenic signaling pathways were largely found. In this review, we tried to draw a full picture of the current state of knowledge on the estrogenic and non-estrogenic effects of BPA with their mechanisms of action through the zebrafish model of the past two decades, which may help to fully understand the endocrine-disrupting effects of BPA and its action mechanism, and give a direction for the future studies. |
| Keyword | Bisphenol A Epigenetics Estrogenic effects Non-estrogenic effects Oxidative stress Transgenerational inheritance Zebrafish |
| DOI | 10.1016/j.envint.2023.107976 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85160073008 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Area, School of Life Sciences, Jiaying University, Meizhou, 514015, China 2.Department of Biomedical Sciences and Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China 3.State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 315211, China |
| First Author Affilication | Centre of Reproduction, Development and Aging |
| Recommended Citation GB/T 7714 | Yuan, Mingzhe,Chen, Shan,Zeng, Chu,et al. Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work[J]. Environment International, 2023, 176. |
| APA | Yuan, Mingzhe., Chen, Shan., Zeng, Chu., Fan, Yuqin., Ge, Wei., & Chen, Weiting (2023). Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work. Environment International, 176. |
| MLA | Yuan, Mingzhe,et al."Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work".Environment International 176(2023). |
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