| Residential College | false |
| Status | 已發表Published |
| Recent progress in nanozymes for the treatment of diabetic wounds | |
| Jiang, Jingai1; Li, Xiao3; Li, Hui1; Lv, Xinyi1; Xu, Yan1; Hu, Yanling2,3; Song, Yanni1; Shao, Jinjun1; Li, Shengke4; Yang, Dongliang1 | |
| 2023-06-02 | |
| Source Publication | Journal of Materials Chemistry B
 |
| ISSN | 2050-750X |
| Volume | 11Issue:29Pages:6746-6761 |
| Abstract | The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open wounds are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in the treatment of diabetic wounds. However, drug-resistant bacteria will develop after long-term use of antibiotics, resulting in decreased efficacy. To improve the therapeutic effect, increasing drug concentration is a common strategy in clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or surgical debridement can easily bring negative effects to patients, such as hypoglycemia or damage of normal tissue. Therefore, it is essential to develop novel therapeutic strategies to effectively promote diabetic wound healing. In recent years, nanozyme-based diabetic wound therapeutic systems have received extensive attention because they possess the advantages of nanomaterials and natural enzymes. For example, nanozymes have the advantages of a small size and a high surface area to volume ratio, which can enhance the tissue penetration of nanozymes and increase the reactive active sites. Moreover, compared with natural enzymes, nanozymes have more stable catalytic activity, lower production cost, and stronger operability. In this review, we first reviewed the basic characteristics of diabetic wounds and then elaborated on the catalytic mechanism and action principle of different types of nanozymes in diabetic wounds from three aspects: controlling bacterial infection, controlling hyperglycemia, and relieving inflammation. Finally, the challenges, prospects and future implementation of nanozymes for diabetic wound healing are outlined. |
| DOI | 10.1039/d3tb00803g |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85164101731 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.School of Physical and Mathematical Sciences, Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, China 2.Nanjing Polytechnic Institute, Nanjing, 210048, China 3.State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China 4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao |
| Recommended Citation GB/T 7714 | Jiang, Jingai,Li, Xiao,Li, Hui,et al. Recent progress in nanozymes for the treatment of diabetic wounds[J]. Journal of Materials Chemistry B, 2023, 11(29), 6746-6761. |
| APA | Jiang, Jingai., Li, Xiao., Li, Hui., Lv, Xinyi., Xu, Yan., Hu, Yanling., Song, Yanni., Shao, Jinjun., Li, Shengke., & Yang, Dongliang (2023). Recent progress in nanozymes for the treatment of diabetic wounds. Journal of Materials Chemistry B, 11(29), 6746-6761. |
| MLA | Jiang, Jingai,et al."Recent progress in nanozymes for the treatment of diabetic wounds".Journal of Materials Chemistry B 11.29(2023):6746-6761. |
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