A method of mechanism analysis about a traditional chinese medicine prescription on a disease based on PageRank algorithm and network pharmacology

doi:10.1016/j.prmcm.2021.100016

UM > Institute of Chinese Medical Sciences

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	A method of mechanism analysis about a traditional chinese medicine prescription on a disease based on PageRank algorithm and network pharmacology
	Xiong, Zhenwen 1; (Victor) Chan, Wai Kin 1; Kuan, Chiungying 1; Hu, Yuanjia2 ; Zhang, Daiyan 2
	2022-06-01
Source Publication	Pharmacological Research - Modern Chinese Medicine
Volume	3
Abstract	Network pharmacology is a method to study the mechanism of a Traditional Chinese Medicine (TCM) prescription on a disease. However, most articles using network pharmacology to study the mechanism did not combine the weight information of herbs, the weight information of targets of disease, and the interaction information between targets together. We propose a method, network pharmacology combined with two iterations of PageRank algorithm, to make use of these information. It takes prescription-disease system as a whole, calculates PageRank score of targets in the prescription-disease system, which means an importance in the system, and the score is used to rank the analysis results of GO and KEGG pathway which help us to analyze the mechanism of a prescription on a disease. At last, we use two prescription-disease pairs which have been proved effectiveness in clinical trials: Qingfei Paidu Decoction on COVID-19, and FuFang DanShen Diwan on Coronary Heart Disease, and find that the results of our method are consistent with some results of clinical trials.
Keyword	Mechanism research Network pharmacology Pagerank algorithm
DOI	10.1016/j.prmcm.2021.100016
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85139041037
Fulltext Access	View Full-Text via DOI View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Affiliation	1.Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, 518055, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
Recommended Citation GB/T 7714	Xiong, Zhenwen,Kuan, Chiungying,et al. A method of mechanism analysis about a traditional chinese medicine prescription on a disease based on PageRank algorithm and network pharmacology[J]. Pharmacological Research - Modern Chinese Medicine, 2022, 3.
APA	Xiong, Zhenwen., ., Kuan, Chiungying., Hu, Yuanjia., & Zhang, Daiyan (2022). A method of mechanism analysis about a traditional chinese medicine prescription on a disease based on PageRank algorithm and network pharmacology. Pharmacological Research - Modern Chinese Medicine, 3.
MLA	Xiong, Zhenwen,et al."A method of mechanism analysis about a traditional chinese medicine prescription on a disease based on PageRank algorithm and network pharmacology".Pharmacological Research - Modern Chinese Medicine 3(2022).

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