Image instance segmentation is a fundamental research topic in autonomous driving, which is crucial for scene understanding and road safety. Advanced learning-based approaches often rely on the costly 2D mask annotations for training. In this paper, we present a more artful framework, LiDAR-guided Weakly Supervised Instance Segmentation (LWSIS), which leverages the off-the-shelf 3D data, i.e., Point Cloud, together with the 3D boxes, as natural weak supervisions for training the 2D image instance segmentation models. Our LWSIS not only exploits the complementary information in multimodal data during training, but also significantly reduces the annotation cost of the dense 2D masks. In detail, LWSIS consists of two crucial modules, Point Label Assignment (PLA) and Graph-based Consistency Regularization (GCR). The former module aims to automatically assign the 3D point cloud as 2D point-wise labels, while the latter further refines the predictions by enforcing geometry and appearance consistency of the multimodal data. Moreover, we conduct a secondary instance segmentation annotation on the nuScenes, named nuInsSeg, to encourage further research on multimodal perception tasks. Extensive experiments on the nuInsSeg, as well as the large-scale Waymo, show that LWSIS can substantially improve existing weakly supervised segmentation models by only involving 3D data during training. Additionally, LWSIS can also be incorporated into 3D object detectors like PointPainting to boost the 3D detection performance for free. The code and dataset are available at https://github.com/Serenos/LWSIS.