This research paper analyzes the last five decades of Sino-Portuguese relations and anticipates the future of this bilateral relationship, ten years after the inception of the Belt and Road Initiative (B&RI). These five decades can be divided into three major periods and seven phases. On the one hand, in 2013, capitalizing on the transformation of its economy, China launched the B&RI. This initiative can be perceived as a major global infrastructural, multi-sectoral, and multi-actor economic policy, designed not only to foster access with consent to markets and production centers, but also to contribute to creating a network of economic flows (Leandro & Duarte, 2020b, p. xii) as well as to advance new forms of interaction for development, and perhaps even a new model for international relations. On another hand, Portugal regards the B&RI as an opportunity to continue de-bordering (Leandro & Duarte, 2020a), capitalizing on the unique advantages of Sino-Portuguese diplomatic relations, namely the Portuguese heritage in the Macau SAR, Portugal’s membership in the Community of the Portuguese-speaking countries, where it is the second most important economy, its European Union (EU) membership, and its position as one of the world’s top 50 most dynamic economies. The B&RI has the potential to reduce the peripheral geographic condition of Portugal in the context of the EU space, explore the immense opportunities offered by the expansion of the continental shelf in the context of the strategic Portuguese triangle (Azores-Madeira-Continental Portugal), and redesign its cooperative relations among Portuguese-speaking countries, among which Portugal ranks first in the “doing business index” (2022). These different phases, perspectives, and interests lead to the formulation of our research question: Based on the B&RI and the unique relationship between China and Portugal, what can we expect from the future of Sino-Portuguese cooperation? This question is particularly important in the context of the current geo-economic tensions between global economic powers, and the fact that Portugal is an EU member state. This paper adopts an economic diplomacy model as a main reference.