| Status | 已發表Published |
| Compartmentation of metabolites in regulating epigenome of cancer | |
| Wang, L. | |
| 2016-04-18 | |
| Source Publication | Molecular Medicine
 |
| ISSN | N/A |
| Pages | N/A-N/A |
| Abstract | Covalent modification of DNA and histones are important epigenetic events and the genome wide reshaping of epigenetic markers is common in cancer. The epigenetic markers are produced by enzymatic reactions and some of these reactions require the presence of metabolites as cofactors (termed Epigenetic Enzyme Required Metabolites, EERMs). Recent studies found that the abundance of these EERMs correlates with epigenetic enzymes activity. Also, the subcellular compartmentation, especially the nuclear localization of these EERMs may play a role in regulating the activities of epigenetic enzymes. Moreover, gene specific recruitment of enzymes which produce the EERMs in the proximity of the epigenetic modification events accompanying the gene expression regulation, were proposed. Therefore, it is of importance to summarize these findings of the EERMs in regulating the epigenetic modifications at both DNA and histone levels, and to understand how EERMs contribute to cancer development by addressing their global versus local distribution. |
| Keyword | DNA methylation EERM Epigenetics cancer cell metabolism gene regulation histone modification metabolites |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 20467 |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Recommended Citation GB/T 7714 | Wang, L.. Compartmentation of metabolites in regulating epigenome of cancer[J]. Molecular Medicine, 2016, N/A-N/A. |
| APA | Wang, L..(2016). Compartmentation of metabolites in regulating epigenome of cancer. Molecular Medicine, N/A-N/A. |
| MLA | Wang, L.."Compartmentation of metabolites in regulating epigenome of cancer".Molecular Medicine (2016):N/A-N/A. |
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