Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer
	Wang, Y; Hao, D; Li, J; Wang, L.; Di, L.
	2017-06-02
Source Publication	Oncotarget
ISSN	1949-2553.
Pages	44705-44719
Abstract	Enhancer is critical cis regulatory elements in gene expression. To understand whether and how the aberrant enhancer activation may contribute to cancer risk, the differentially methylated enhancers (eDMRs) in normal and malignant breast tissues were identified and analyzed. By incorporating genome-wide chromatin interaction, integrated analysis of eDMRs and target gene expression identified 1,272 enhancer-promoter pairs. Surprisingly, two functionally distinct groups of genes were identified in these pairs, one showing better correlation to enhancer methylation (eRGs) and the other showing better correlation to promoter methylation (pRGs), and the former group is functionally enriched with cancer related genes. Moreover, enhancer methylation based clustering of breast cancer samples is capable of discriminating basal breast cancer from other subtypes. By correlating enhancer methylation status to patient survival, 345 enhancers show the impact on the disease outcome and the majority of their target genes are important regulators of cell survival pathways including known cancer related genes. Together, these results suggest reactivation of enhancers in cancer cells has the add-on effect and contributes to cancer risk in combination.
Keyword	enhancer methylation breast cancer chromatin interaction polII ChIA-PET gene regulation
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	31315
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Di, L.
Recommended Citation GB/T 7714	Wang, Y,Hao, D,Li, J,et al. Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer[J]. Oncotarget, 2017, 44705-44719.
APA	Wang, Y., Hao, D., Li, J., Wang, L.., & Di, L. (2017). Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer. Oncotarget, 44705-44719.
MLA	Wang, Y,et al."Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer".Oncotarget (2017):44705-44719.

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