| Status | 已發表Published |
| GSK3 activated STAT5 regulates expression o SFRPs to modulate adipogenesis | |
Wang, L. ; Wang, YW ; Meng, YM; Zhang, CZ; Di, L.
| |
| 2018-03-01 | |
| Source Publication | FASEB J
 |
| ISSN | 0892-6638 |
| Pages | 1-12 |
| Abstract | Adipogenesis is a tightly regulated cellular process and is closely associated with obesity and its associated metabolic disorders such as Diabetes. Multiple transcription factors and signaling pathways are involved in the regulation of adipogenesis. Here, we report that Glycogen synthase kinase (GSK3), which was reported to play an important role in many cellular processes, is essential to adipocyte differentiation at early and terminal differentiation phase. Mechanistically, GSK3 modulates adipogenesis through regulating both canonical Wnt pathways which involve Wnt/β-catenin signaling and noncanonical Wnt pathways which include JNK and RAC signalings. GSK3 regulated adipogenesis is also be mediated by SFRPs especially SFRP1, the canonical Wnt antagonist. The obesity-induced increase of Sfrp1 expression can be reversed by the GSK3 inhibitor. GSK3 regulated expression of Sfrps is mediated by STAT5. We demonstrated that GSK3 activates STAT5 through regulating its phosphorylation to bind to the promoter of Sfrp genes and PPARγ gene to stimulate their expression, which could ultimately lead to modulated adipogenic process. Our findings identify a GSK3/STAT5/SFRPs/Wnt regulatory axis of adipogenesis and shed light on the molecular mechanism of adipogenesis by suggesting that different pathways and adipogenic regulators coordinately modulate adipocyte differentiation. |
| Keyword | adipocyte differentiation GSK3 Wnt pathway |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 35887 |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Wang, L.; Di, L. |
| Recommended Citation GB/T 7714 | Wang, L.,Wang, YW,Meng, YM,et al. GSK3 activated STAT5 regulates expression o SFRPs to modulate adipogenesis[J]. FASEB J, 2018, 1-12. |
| APA | Wang, L.., Wang, YW., Meng, YM., Zhang, CZ., & Di, L. (2018). GSK3 activated STAT5 regulates expression o SFRPs to modulate adipogenesis. FASEB J, 1-12. |
| MLA | Wang, L.,et al."GSK3 activated STAT5 regulates expression o SFRPs to modulate adipogenesis".FASEB J (2018):1-12. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment