An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion

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Status	已發表Published
	An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion
	Wang, Y; Wang, L.; Di, L.
	2020-12-01
Source Publication	Frontiers in genetics
ISSN	1664-8021
Pages	1483-1489
Abstract	Cancer is characterized by dysregulation at multiple levels, such as gene transcription. Enhancers are well-studied transcription regulators that can enhance target transcripts through DNA loop formation mediated by chromosome folding. The gain or loss of the interaction between an enhancer and its target gene has a critical effect on gene expression. In this study, we analyzed GRO-seq data to identify active enhancers from 7 common cancer cell lines and studied the function of these enhancers across multiple cancer types. By constructing an ‘enhancer effect score’ (EES), we found a significant correlation between EES and tumor-infiltrating lymphocytes (TILs) in prostate cancer. Further analysis revealed that AR plays an important role in regulating the immune checkpoint gene PVR via its enhancer. These results suggest that AR contributes to prostate cancer aggressiveness by promoting cancer cell immune evasion.
Keyword	enhancer androgen receptor
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	59309
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Di, L.
Recommended Citation GB/T 7714	Wang, Y,Wang, L.,Di, L.. An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion[J]. Frontiers in genetics, 2020, 1483-1489.
APA	Wang, Y., Wang, L.., & Di, L. (2020). An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion. Frontiers in genetics, 1483-1489.
MLA	Wang, Y,et al."An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion".Frontiers in genetics (2020):1483-1489.

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