| Status | 已發表Published |
| Spectrin: structure, function and disease | |
Zhang, R.; Zhang, G.; Zhao, Q.; Li, D.
| |
| 2013-12-05 | |
| Source Publication | Science China Life Sciences
 |
| ISSN | 1674-7305 |
| Pages | 1076-1085 |
| Abstract | Spectrin is a large, cytoskeletal, and heterodimeric protein composed of modular structure of α and β subunits, it typically contains 106 contiguous amino acid sequence motifs called "spectrin repeats". Spectrin is crucial for maintaining the stability and structure of the cell membrane and the shape of a cell. Moreover, it contributes to diverse cell functions such as cell adhesion, cell spreading, and the cell cycle. Mutations of spectrin lead to various human diseases such as hereditary hemolytic anemia, type 5 spinocerebellar ataxia, cancer, as well as others. This review focuses on recent advances in determining the structure and function of spectrin as well as its role in disease. |
| Keyword | erythrocyte spectrin cell cycle mass spectrometry disease |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 55332 |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Li, D. |
| Recommended Citation GB/T 7714 | Zhang, R.,Zhang, G.,Zhao, Q.,et al. Spectrin: structure, function and disease[J]. Science China Life Sciences, 2013, 1076-1085. |
| APA | Zhang, R.., Zhang, G.., Zhao, Q.., & Li, D. (2013). Spectrin: structure, function and disease. Science China Life Sciences, 1076-1085. |
| MLA | Zhang, R.,et al."Spectrin: structure, function and disease".Science China Life Sciences (2013):1076-1085. |
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