| Status | 已發表Published |
| 中国化学会第30届学术年会 | |
Wu, Y.; Chen, Z. ; Zhang, P. ; Li, C.; Zhou, L.; Jiang, T.; Gong, P.; Zhao, Q.; Cai, L.
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| 2016-07-01 | |
| Source Publication | Highly Stable and Clickable Semiconducting Polymer Dots Conjugated with Anti-Her2-scFv for Tumor Cells Labeling and Near-Infrared Imaging
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| Abstract | We successfully designed and synthesized new kinds of PEG grafted amphiphilic co-block polymers, which were able to encapsulate hydrophobic semiconducting polymers to obtain compact, highly stable, highly luminescent and biocompatible near-infrared polymer dots. After surface modification with DBCO functional groups, the acquired clickable polymer dots were efficiently conjugated with azide modified Anti-Her2-scFv fragmented antibody via click chemistry and displayed splendid specific targeting property to expressed Her2 receptors of SKBR-3 cells. This resulted fluorescent probes showed great potential in cell labeling and near-infrared imaging of tumor cells. |
| Keyword | 聚合物点 点击化学 Her2受体 纳米探针 荧光成像 |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 55411 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Zhang, P.; Zhao, Q.; Cai, L. |
| Recommended Citation GB/T 7714 | Wu, Y.,Chen, Z.,Zhang, P.,等. 中国化学会第30届学术年会[C], 2016. |
| APA | Wu, Y.., Chen, Z.., Zhang, P.., Li, C.., Zhou, L.., Jiang, T.., Gong, P.., Zhao, Q.., & Cai, L. (2016). 中国化学会第30届学术年会. Highly Stable and Clickable Semiconducting Polymer Dots Conjugated with Anti-Her2-scFv for Tumor Cells Labeling and Near-Infrared Imaging. |
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