Generation of Bispecific Antibodies by Fc Heterodimerization and their Application

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	Generation of Bispecific Antibodies by Fc Heterodimerization and their Application
	Chen, Z.; Wang, L; Xu, T; Wang, Q; Kang, L; Zhao, Q.
	2016-10-18
Source Publication	Current Pharmaceutical Biotechnology
ISSN	1389-2010
Pages	1324-1332
Abstract	Bispecific antibodies with binding specificities for two different antigens have prompted a lot of interest into their development and application. Currently, more than ten bispecific antibodies have been clinically validated for the treatment of various diseases, including cancers and inflammatory diseases. Intensive studies in antibody engineering drive the generation of different bispecific antibody formats that differ in size and shape. However, the most prominent formats, such as IgG-single-chain (sc) Fv or dual-variable domain (DVD) IgG, deviating from the natural IgG structure, may lead to manufacturing difficulties or increase the potential risk of immunogenicity. Thus, the recent efforts focus on the development of bispecific antibodies by Fc heterodimerization that maintain the native structure of the antibody IgG molecule. This review summarizes the various techniques and methods to generate bispecific antibody molecules with Fc heterodimerization, and discusses perspectives of their application.
Keyword	Bispecific antibody Fc heterodimerization quadroma Knobs-into-holes strand-exchange engineered domain
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	28284
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Zhao, Q.
Recommended Citation GB/T 7714	Chen, Z.,Wang, L,Xu, T,et al. Generation of Bispecific Antibodies by Fc Heterodimerization and their Application[J]. Current Pharmaceutical Biotechnology, 2016, 1324-1332.
APA	Chen, Z.., Wang, L., Xu, T., Wang, Q., Kang, L., & Zhao, Q. (2016). Generation of Bispecific Antibodies by Fc Heterodimerization and their Application. Current Pharmaceutical Biotechnology, 1324-1332.
MLA	Chen, Z.,et al."Generation of Bispecific Antibodies by Fc Heterodimerization and their Application".Current Pharmaceutical Biotechnology (2016):1324-1332.

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