| Status | 已發表Published |
| Immunogenomic analyses of advanced serous ovarian cancer reveal immunoscore is a strong prognostic factor and a predictor of chemo-sensitivity | |
Hao, DH ; Liu, JL; Chen, MC; Li, JL; Wang, L.; Li, XL; Zhao, Q.; Di, L.
| |
| 2018-03-01 | |
| Source Publication | Clinical Cancer Research
 |
| ISSN | 1078-0432 |
| Pages | 1-13 |
| Abstract | Purpose: Ovarian cancer is one of the first human cancers for which in situ immune response was reported to be important for clinical outcome. To elucidate the mechanistic relationship between immune repertoire and cancer genotype in ovarian cancer, the development of a well-defined immunoscore for ovarian cancer is required. Experimental Design: From a collection of 2,203 patient samples of advanced ovarian cancer, we evaluated the prognostic values for a compendium of immune marker genes and proposed an immunoscore. The relationships between immunoscore, tumor-infiltrating immune cells, cancer genotypes and their impact on patient outcome were characterized. Results: Loss of chemokine and IFN-γ pathway genes is frequent in ovarian cancer and is significantly associated with low immunoscore and poor outcome. Chemotherapy can increase the immunoscore of tumors by inducing the expression of IFN-γ inducible chemokines. High immunoscore is significantly associated with BRCA1/2 mutation status and the response to chemotherapy. Multivariate analysis revealed that immunoscore is a strong predictor of patient survival and the response to immunotherapy. Conclusions: Our results reveal the drivers of immune repertoire of advanced ovarian cancer and demonstrate the importance of immunoscore as an independent prognostic signature and a potent indicator of intratumoral immune status. |
| Keyword | Ovarian Cancer Immunoscore immuno therapy immunogenomic |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 35888 |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Recommended Citation GB/T 7714 | Hao, DH,Liu, JL,Chen, MC,et al. Immunogenomic analyses of advanced serous ovarian cancer reveal immunoscore is a strong prognostic factor and a predictor of chemo-sensitivity[J]. Clinical Cancer Research, 2018, 1-13. |
| APA | Hao, DH., Liu, JL., Chen, MC., Li, JL., Wang, L.., Li, XL., Zhao, Q.., & Di, L. (2018). Immunogenomic analyses of advanced serous ovarian cancer reveal immunoscore is a strong prognostic factor and a predictor of chemo-sensitivity. Clinical Cancer Research, 1-13. |
| MLA | Hao, DH,et al."Immunogenomic analyses of advanced serous ovarian cancer reveal immunoscore is a strong prognostic factor and a predictor of chemo-sensitivity".Clinical Cancer Research (2018):1-13. |
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