The goal of this study is to investigate the structural performance of reinforced concrete building under the influence of severe typhoon. For this purpose, full-scale monitoring of a 22-story reinforced concrete building was conducted during the entire passage process of a severe typhoon "Vicente." Vicente was the eighth tropical storm developed in the Western North Pacific Ocean and the South China Sea in 2012. Moreover, it was the strongest and most devastating typhoon that struck Macao since 1999. The overall duration of the typhoon affected period that lasted more than 70 hours and the typhoon eye region covered Macao for around one hour. The wind and structural response measurements were acquired throughout the entire typhoon affected period. The wind characteristics were analyzed using the measured wind data including the wind speed and wind direction time histories. Besides, the structural response measurements of the monitored building were utilized for modal identification using the Bayesian spectral density approach. Detailed analysis of the field data and the typhoon generated effects on the structural performance are discussed. © 2013 Sin-Chi Kuok and Ka-Veng Yuen.