Traditional Gothic imagery of death and ruin, ghosts and vampires, contagion and conspiracy theory has flourished in the Western media as ways of representing and imagining the threat and impact of the Covid-19 coronavirus. This is not new: Gothic superstition has mixed with medical science for centuries to try to explain epidemic infection, and vampires, for instance, have been seen as vectors of plague. Consequently, depictions of vampires have shadowed medical practice, embracing and assimilating new advances in bioscience, as well as becoming instrumental in theological, philosophical, and economic thought, and so even today the language of vampires and vampirology can cast a light on the contemporary experience of epidemic measures. Yet at the same time a new Gothic imagery is emerging based not around monstrosity but emphasizing the non-human and the unknown: the ‘weird’ and the ‘eerie’. The relationship between these two reformulations of the Gothic is as yet unpredictable, but it is likely to have long-lasting impact on literature and film, language and culture.